Document Detail

Early adverse care, stress neurobiology, and prevention science: lessons learned.
MedLine Citation:
PMID:  23420476     Owner:  NLM     Status:  MEDLINE    
There is growing evidence that some of the difficulties observed among children who have experienced early adverse care (e.g., children internationally adopted from institutional care and maltreated children in foster care) involve experience-induced alterations in stress-responsive neurobiological systems, including the hypothalamic-pituitary-adrenocortical (HPA) system. Thus, incorporating stress neurobiology into prevention research could aid in identifying the children most in need of preventive intervention services, elucidating the mechanisms of change in effective interventions, and providing insight into the differential responses of children to effective interventions. However, integrating stress neurobiology and prevention research is challenging. In this paper, the results of studies examining HPA system activity in children who have experienced early adverse care are reviewed, the implications of these results for prevention research are discussed, and critical steps for successfully incorporating stress neurobiology into prevention research are identified.
Jacqueline Bruce; Megan R Gunnar; Katherine C Pears; Philip A Fisher
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Prevention science : the official journal of the Society for Prevention Research     Volume:  14     ISSN:  1573-6695     ISO Abbreviation:  Prev Sci     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-04-22     Completed Date:  2013-10-21     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  100894724     Medline TA:  Prev Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  247-56     Citation Subset:  IM    
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MeSH Terms
Hypothalamo-Hypophyseal System
Pituitary-Adrenal System
Stress, Psychological / physiopathology,  prevention & control*
Grant Support

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