Document Detail


Earliest lymphoid colonization of neonatal rat lymph nodes: an antigen-specific process?
MedLine Citation:
PMID:  11510967     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present work studied the little known process of lymphoid cell colonization of neonatal lymph nodes, while considering the nodal site of entry of circulating lymphoid cells and the either random or antigen-specific character of the process. Tissue sections of a mesenteric, cervical and popliteal node from each of 57 rats, aged 4 hours to 3 weeks, were analysed. Observations bear on the relative importance of the implication of the subcapsular sinus versus venules of nodes, and the composition of their emerging lymphoid cell population by determining the proportion of lymphocytes and blast-related cells. At 16-20 hours after birth, cell counts yielded a mean proportion of 84% for blast-related cells which decreased to 18% at 3 weeks. These percentages are compatible with values expected for a selective antigen-specific entry of lymphoid cells in nodes, not with values that would result from a random entry of lymphocytes. Moreover, observations revealed that by far most colonizing cells initially enter nodes carried by the afferent lymph, little via their venules.
Authors:
G Sainte-Marie
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Histology and histopathology     Volume:  16     ISSN:  0213-3911     ISO Abbreviation:  Histol. Histopathol.     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-08-20     Completed Date:  2002-02-08     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8609357     Medline TA:  Histol Histopathol     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  771-83     Citation Subset:  IM    
Affiliation:
Département de pathologie et biologie cellulaire, Université de Montréal, Québec, Canada.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Animals
Animals, Newborn
Antigens
Cell Count
Cell Movement
Female
Lymph / cytology
Lymph Nodes / cytology,  growth & development*,  immunology*
Lymphocytes / cytology,  immunology,  physiology
Male
Rats
Rats, Sprague-Dawley
Chemical
Reg. No./Substance:
0/Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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