Document Detail

Earliest Stage of the Tetrahedral Nanochannel Formation in Cubosome Particles from Unilamellar Nanovesicles.
MedLine Citation:
PMID:  23148665     Owner:  NLM     Status:  Publisher    
Studies of nonequilibrium lipid polymorphism at the nanoscale contribute to the in-depth understanding of the structural pathways for formation of aqueous channels and emerging of channels-network ordering in liquid-crystalline (LC) nanovehicles. We present experimental structural evidence for the smallest tetrahedral-type lipid membrane aggregate, which involves completely formed nanochannels and occurs as an early intermediate state during the bilayer vesicle-to-cubosome particle transition. Nanovehicles are generated from a self-assembled lipid mixture and studied by means of high-resolution cryogenic transmission electron microscopy (cryo-TEM) and synchrotron radiation small-angle X-ray scattering (SAXS). The investigated lipid membrane composition allows for the stabilization of long-lived intermediates throughout the unilamellar vesicle-to-cubosome nanoparticle (NP) transformation at ambient temperature. The observed small cubosomic particles, with well-defined water channels, appear to be precursors of larger cubic membrane structures, thus confirming the theoretical modeling of nanochannel-network growth in diamond-type cubic lipid particles. The reported structural findings, highlighting that bilayer vesicle membrane packing and fusion are required for nanochanneled cubosome particle formation, are anticipated to advance the engineering of small lipid NPs with controllable channels for biomolecular loading and release.
Borislav Angelov; Angelina Angelova; Vasil M Garamus; Markus Drechsler; Regine Willumeit; Rada Mutafchieva; Petr Stěpánek; Sylviane Lesieur
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-14
Journal Detail:
Title:  Langmuir : the ACS journal of surfaces and colloids     Volume:  -     ISSN:  1520-5827     ISO Abbreviation:  Langmuir     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9882736     Medline TA:  Langmuir     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic , Heyrovskeho nam. 2, CZ-16206 Prague, Czech Republic.
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