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Ear Keloids as a Primary Candidate for the Application of Mitomycin C after Shave Excision: In Vivo and In Vitro Study.
MedLine Citation:
PMID:  21269347     Owner:  NLM     Status:  Publisher    
BACKGROUND Although many methods have been developed to treat ear keloids, new therapeutic options are still needed. OBJECTIVE To determine the effects of topical mitomycin C (MC) on shave-removed wounds and fibroblasts of ear keloids. METHODS Fourteen ear keloids in 12 patients were shaved, and MC (1 mg/mL) was applied to the resected bed for 5 minutes. The application was repeated 3 weeks later. All patients were assessed 2, 4, and 6 months after the procedure to evaluate the cosmetic results, recurrence, and postsurgical complications. An in vitro study to determine the effects of MC on fibroblasts of the excised keloids was conducted using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, the measurement of total cell counts, and immunoassay of DNA synthesis. RESULTS Only one recurrence occurred (on the ear helix), and the patients were satisfied with the cosmetic outcomes. The results of the MTT assay, total cell counts, and DNA synthesis immunoassay confirmed the suppressive effects of MC on the keloid fibroblasts. CONCLUSION The application of topical MC to the resected bed of shave-removed ear keloids was successful in preventing recurrences and providing an acceptable cosmetic outcome. The authors have indicated no significant interest with commercial supporters.
Seong Geun Chi; Jun Young Kim; Weon Ju Lee; Seok-Jong Lee; DO Won Kim; Mi Yeung Sohn; Gun Wook Kim; Moon Bum Kim; Byung Soo Kim
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-26
Journal Detail:
Title:  Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]     Volume:  -     ISSN:  1524-4725     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9504371     Medline TA:  Dermatol Surg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 by the American Society for Dermatologic Surgery, Inc.
Departments of Dermatology and Immunology, Kyungpook National University School of Medicine, Daegu, Republic of Korea Department of Dermatology, Pusan National University School of Medicine, Busan, Republic of Korea Medical Research Institute, Pusan National University, Busan, Korea.
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