Document Detail


Eales disease--an update.
MedLine Citation:
PMID:  12052408     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Eales disease, first described by Henry Eales in 1880, remains an enigma. The disease, observed more commonly in the Indian subcontinent than in the rest of the world, occurs in young healthy adult males, initially presenting as retinal periphlebitis and later as retinal ischemia that may lead to vascular alterations and neovascularization. Recurrent vitreous hemorrhage with or without retinal detachment is the common sequelae. In recent years, immunological, molecular biological, and biochemical studies have indicated the role of human leukocyte antigen, retinal autoimmunity, mycobacterium tuberculosis genome, and free radical mediated damage in the etiopathogenesis of this disease. However, its etiology appears to be multifactorial. The management depends on the stage of the disease and consists of medical treatment with oral corticosteroids in the active inflammatory stage and laser photocoagulation in the advanced retinal ischemia and neovascularization stages. The results of vitreoretinal surgery have been found to be satisfactory in case of vitreous hemorrhage with or without retinal detachment.
Authors:
Jyotirmay Biswas; Tarun Sharma; Lingam Gopal; Hajib N Madhavan; K N Sulochana; S Ramakrishnan
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Survey of ophthalmology     Volume:  47     ISSN:  0039-6257     ISO Abbreviation:  Surv Ophthalmol     Publication Date:    2002 May-Jun
Date Detail:
Created Date:  2002-06-07     Completed Date:  2002-08-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0404551     Medline TA:  Surv Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  197-214     Citation Subset:  IM    
Affiliation:
Medical and Vision Research Foundations, Chennai, India.
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MeSH Terms
Descriptor/Qualifier:
Diagnosis, Differential
Diagnostic Techniques, Ophthalmological
Humans
Ophthalmologic Surgical Procedures
Retinal Diseases / complications*,  diagnosis,  therapy
Retinal Vessels / pathology*
Vasculitis / complications*,  diagnosis,  therapy
Vitreous Hemorrhage / diagnosis,  etiology,  therapy

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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