Document Detail


EUK-8 a synthetic catalytic scavenger of reactive oxygen species protects isolated iron-overloaded rat heart from functional and structural damage induced by ischemia/reperfusion.
MedLine Citation:
PMID:  8877076     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of EUK-8, a synthetic, catalytic scavenger of reactive oxygen species, on isolated iron-overloaded rat hearts submitted to ischemia-reperfusion were studied. In the absence of EUK-8, functional parameters (systolic and diastolic pressures, oxygen consumption as estimated by the product heart rate times left ventricular diastolic pressure) were severely impaired 1 minute and 15 minutes after reperfusion following a 15 minute ischemic episode. Dimethylthiourea (10 mM), a hydroxyl radical scavenger, had a minimally protective effect. In contrast, EUK-8 at a concentration of 50 microM in the perfusion medium maintained these parameters at close to their preischemia values. Electron microscopic analysis of heart tissues after 15 minutes ischemia followed by 15 minutes reperfusion showed extensive damage to mitochondria and sarcomeres in untreated hearts, while the extent of damage was significantly lower in EUK-8-treated hearts. The functional and structural protection afforded by EUK-8 were significantly better than those induced by dimethylthiourea. These data suggest that EUK-8 may be therapeutically useful in preventing heart damage induced by ischemia-reperfusion, for example, during thrombolytic treatment of myocardial infarction.
Authors:
S Pucheu; F Boucher; T Sulpice; N Tresallet; Y Bonhomme; B Malfroy; J de Leiris
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy     Volume:  10     ISSN:  0920-3206     ISO Abbreviation:  Cardiovasc Drugs Ther     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1997-01-14     Completed Date:  1997-01-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8712220     Medline TA:  Cardiovasc Drugs Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  331-9     Citation Subset:  IM    
Affiliation:
Groupe de Physiopathologie Cellulaire Cardiaque, URA CNRS, Université Joseph Fourier, Grenoble, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects
Dextrans / administration & dosage,  toxicity
Disease Models, Animal
Electron Spin Resonance Spectroscopy
Ethylenediamines / pharmacology*
Female
Free Radical Scavengers / pharmacology*,  therapeutic use
Heart Rate / drug effects
Heart Ventricles / drug effects*,  ultrastructure
Iron / administration & dosage,  toxicity
Manganese / metabolism
Microscopy, Electron
Mitochondria, Heart / drug effects,  ultrastructure
Myocardial Infarction / drug therapy
Myocardial Reperfusion Injury / prevention & control*
Organometallic Compounds / pharmacology*
Oxygen Consumption / drug effects
Rats
Rats, Wistar
Reactive Oxygen Species
Thiourea / analogs & derivatives,  pharmacology,  therapeutic use
Chemical
Reg. No./Substance:
0/Ethylenediamines; 0/Free Radical Scavengers; 0/Organometallic Compounds; 0/Reactive Oxygen Species; 53177-12-1/N,N'-bis(salicylideneamino)ethane-manganese(II); 61805-96-7/1,3-dimethylthiourea; 62-56-6/Thiourea; 7439-89-6/Iron; 7439-96-5/Manganese; 9004-54-0/Dextrans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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