| EU-funded treatment study: WAKE-UP : A randomized, placebo-controlled MRI-based trial of thrombolysis in wake-up stroke. | |
| | |
MedLine Citation:
|
PMID: 23015193 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Patients waking up with stroke symptoms are generally excluded from intravenous thrombolysis. It was shown that magnetic resonance imaging (MRI) can identify patients within the time window for thrombolysis (≤ 4.5 h from symptom onset) by a mismatch between the acute ischemic lesion visible on diffusion-weighted imaging (DWI) but not visible on fluid-attenuated inversion recovery (FLAIR) imaging. The WAKE-UP trial is an investigator initiated, European, randomized, double-blind, placebo-controlled trial designed to test efficacy and safety of MRI-based thrombolysis with alteplase (tPA) in stroke patients with unknown time of symptom onset, e.g. due to symptom recognition on awakening. A total of 800 patients showing MRI findings of a DWI-FLAIR-mismatch will be randomized to either tPA or placebo. The primary efficacy endpoint will be favourable outcome defined by a modified Rankin scale score 0-1 at day 90. The primary safety outcome measures will be mortality and death or dependency defined by modified Rankin scale score 4-6 at 90 days. If positive the WAKE-UP trial is expected to change clinical practice and to make effective and safe treatment available for a large group of acute stroke patients currently excluded from specific acute treatment. |
| | |
Authors:
|
G Thomalla; M Ebinger; J Fiehler; J B Fiebach; M Endres; C Gerloff |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-9-28 |
Journal Detail:
|
Title: Der Nervenarzt Volume: - ISSN: 1433-0407 ISO Abbreviation: Nervenarzt Publication Date: 2012 Sep |
Date Detail:
|
Created Date: 2012-9-27 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0400773 Medline TA: Nervenarzt Country: - |
Other Details:
|
Languages: GER Pagination: - Citation Subset: - |
Affiliation:
|
Klinik und Poliklinik für Neurologie, Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Deutschland, thomalla@uke.uni-hamburg.de. |
Vernacular Title:
|
EU-geförderte Therapiestudie WAKE-UP : Eine randomisierte, placebokontrollierte, MRT-basierte Thrombolysestudie bei "wake-up stroke" |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Can Land Managers Control Japanese Knotweed? Lessons from Control Tests in Belgium.
Next Document: Experimental therapy approaches for ischemic stroke.