Document Detail

ETV6-NTRK3 gene fusion in a secretory carcinoma of the breast of a male-to-female transsexual.
MedLine Citation:
PMID:  15695086     Owner:  NLM     Status:  MEDLINE    
Secretory carcinomas of the breast were first described as "juvenile carcinoma" by McDivitt and Stewart in a cohort of children. This term has been replaced by the term "secretory breast carcinoma", because the entity can occur at any time of life. Carcinoma of the male breast is uncommon and accounts for approximately 1% of all cancers in men. Recently, it has been reported that human secretory breast carcinoma expresses the ETV6-NTRK3 gene fusion that was previously cloned in pediatric mesenchymal cancers. We present the case of a 46-year-old male-to-female transsexual in whom a secretory breast carcinoma was an incidental finding. As confirmation of the histopathological diagnosis we detected the novel ETV6-NTRK3 gene fusion in this tumor.
F Grabellus; K Worm; A Willruth; K J Schmitz; F Otterbach; H A Baba; R Kimmig; K A Metz
Related Documents :
18558006 - Male breast cancer: is the scenario changing.
19588226 - Intracystic papillary carcinoma of the male breast: a case report and review of the lit...
10866076 - Intracystic papillary carcinoma in the male breast. a case report.
17785986 - Anti-yo-associated paraneoplastic cerebellar degeneration in a man with adenocarcinoma ...
23232686 - Kidney metastasis of invasive ductal breast carcinoma mimicking renal cell carcinoma.
20947266 - Interfractional variations in the setup of pelvic bony anatomy and soft tissue, and the...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Breast (Edinburgh, Scotland)     Volume:  14     ISSN:  0960-9776     ISO Abbreviation:  Breast     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-02-07     Completed Date:  2005-05-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9213011     Medline TA:  Breast     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  71-4     Citation Subset:  IM    
Institute of Pathology, University Hospital of Essen, Hufelandstrasse 55, D-45122 Essen, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Breast Neoplasms, Male / genetics*,  pathology*
Carcinoma / genetics*,  pathology*
DNA, Neoplasm / analysis
Middle Aged
Oncogene Proteins, Fusion / analysis,  biosynthesis*
Reverse Transcriptase Polymerase Chain Reaction
Reg. No./Substance:
0/DNA, Neoplasm; 0/ETV6-NTRK3 fusion protein, human; 0/Oncogene Proteins, Fusion

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Dynamic contrast enhanced magnetic resonance imaging and magnetic resonance spectroscopy in diabetic...
Next Document:  Intravascular large B-cell lymphoma of the breast.