Document Detail


ETV6-NTRK3 gene fusion in a secretory carcinoma of the breast of a male-to-female transsexual.
MedLine Citation:
PMID:  15695086     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Secretory carcinomas of the breast were first described as "juvenile carcinoma" by McDivitt and Stewart in a cohort of children. This term has been replaced by the term "secretory breast carcinoma", because the entity can occur at any time of life. Carcinoma of the male breast is uncommon and accounts for approximately 1% of all cancers in men. Recently, it has been reported that human secretory breast carcinoma expresses the ETV6-NTRK3 gene fusion that was previously cloned in pediatric mesenchymal cancers. We present the case of a 46-year-old male-to-female transsexual in whom a secretory breast carcinoma was an incidental finding. As confirmation of the histopathological diagnosis we detected the novel ETV6-NTRK3 gene fusion in this tumor.
Authors:
F Grabellus; K Worm; A Willruth; K J Schmitz; F Otterbach; H A Baba; R Kimmig; K A Metz
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Breast (Edinburgh, Scotland)     Volume:  14     ISSN:  0960-9776     ISO Abbreviation:  Breast     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-02-07     Completed Date:  2005-05-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9213011     Medline TA:  Breast     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  71-4     Citation Subset:  IM    
Affiliation:
Institute of Pathology, University Hospital of Essen, Hufelandstrasse 55, D-45122 Essen, Germany. florian.grabellus@medizin.uni-essen.de
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MeSH Terms
Descriptor/Qualifier:
Breast Neoplasms, Male / genetics*,  pathology*
Carcinoma / genetics*,  pathology*
DNA, Neoplasm / analysis
Humans
Immunohistochemistry
Male
Middle Aged
Oncogene Proteins, Fusion / analysis,  biosynthesis*
Reverse Transcriptase Polymerase Chain Reaction
Transsexualism*
Chemical
Reg. No./Substance:
0/DNA, Neoplasm; 0/ETV6-NTRK3 fusion protein, human; 0/Oncogene Proteins, Fusion

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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