Document Detail


ESPRIT: is aspirin plus dipyridamole superior to aspirin alone in TIA or minor stroke patients?
MedLine Citation:
PMID:  18986236     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Transient ischemic attack (TIA) or a (minor) ischemic stroke increases the risk of a recurrent stroke or death. Antiplatelet therapy with aspirin or clopidogrel is, in the absence of a potential cardiac embolic source, common practice to lower this risk. Until recently, adjuvant dipyridamole or low intensity oral anticoagulation were not generally prescribed in secondary prevention. In this article, we will summarize and discuss the published results of the European/Australasian Stroke Prevention in Reversible Ischemia Trial (ESPRIT). In this trial, treatments with anticoagulants, aspirin alone and the combination of aspirin plus dipyridamole were compared, in a multicenter, three-armed, randomized, open-label study in patients with TIA or minor stroke.
Authors:
R P W Rouhl; J Lodder
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert review of neurotherapeutics     Volume:  8     ISSN:  1744-8360     ISO Abbreviation:  Expert Rev Neurother     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-06     Completed Date:  2009-02-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101129944     Medline TA:  Expert Rev Neurother     Country:  England    
Other Details:
Languages:  eng     Pagination:  1661-5     Citation Subset:  IM    
Affiliation:
Department of Neurology, Maastricht University Medical Centre, Maastricht, The Netherlands. r.rouhl@mumc.nl
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MeSH Terms
Descriptor/Qualifier:
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*
Aspirin / administration & dosage*
Dipyridamole / administration & dosage*
Drug Therapy, Combination
Female
Humans
Ischemic Attack, Transient / drug therapy*
Male
Middle Aged
Multicenter Studies as Topic
Platelet Aggregation Inhibitors / administration & dosage*
Randomized Controlled Trials as Topic
Stroke / drug therapy*
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Platelet Aggregation Inhibitors; 50-78-2/Aspirin; 58-32-2/Dipyridamole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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