Document Detail

ESH position paper: renal denervation - an interventional therapy of resistant hypertension.
MedLine Citation:
PMID:  22469838     Owner:  NLM     Status:  MEDLINE    
Experts from the European Society of Hypertension prepared this position paper in order to summarize current evidence, unmet needs and practical recommendations on the application of percutaneous transluminal ablation of renal nerves [renal denervation (RDN)] as a novel therapeutic strategy for the treatment of resistant hypertension. The sympathetic nervous activation to the kidney and the sensory afferent signals to the central nervous system represent the targets of RND. Clinical studies have documented that catheter-based RDN decreases both efferent sympathetic and afferent sensory nerve traffic leading to clinically meaningful systolic and diastolic blood pressure (BP) reductions in patients with resistant hypertension. This position statement intends to facilitate a better understanding of the effectiveness, safety, limitations and issues still to be addressed with RDN.
Roland E Schmieder; Josep Redon; Guido Grassi; Sverre E Kjeldsen; Giuseppe Mancia; Krzysztof Narkiewicz; Gianfranco Parati; Luis Ruilope; Philippe van de Borne; Costas Tsioufis
Related Documents :
7977818 - Hypoxic reperfusion after ischemia in swine does not improve acute brain recovery.
7506318 - Comparison of antiarrhythmic and electrophysiologic effects of diltiazem and its analog...
17117228 - Melatonin prevents cardioprotection induced by a multi-cycle ischaemic preconditioning ...
1583008 - The effects of a high dose of ascorbate on ischemia-reperfusion-induced mitochondrial d...
3382328 - The three-dimensional architecture of vasa vasorum in the wall of the human aorta. a co...
11041168 - Nitric oxide is an excitatory modulator in the rostral ventrolateral medulla in rats.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  30     ISSN:  1473-5598     ISO Abbreviation:  J. Hypertens.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-12     Completed Date:  2012-08-13     Revised Date:  2013-01-07    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  837-41     Citation Subset:  IM    
University Hospital Erlangen, Nephrology and Hypertension, Erlangen, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cardiology / methods
Catheter Ablation / methods*
Denervation / methods*
Hypertension / therapy*
Kidney / innervation*
Middle Aged
Neurosurgical Procedures / methods*
Randomized Controlled Trials as Topic
Renal Artery / innervation
Societies, Medical
Sympathetic Nervous System
Treatment Outcome
Comment In:
J Hypertens. 2012 Dec;30(12):2441-2; author reply 2443   [PMID:  23151886 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Development of structural kidney damage in spontaneously hypertensive rats.
Next Document:  Downregulation of cylindromatosis gene, CYLD, confers a growth advantage on malignant melanoma cells...