| ERP effects of methylphenidate and working memory load in healthy adults during a serial visual working memory task. | |
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MedLine Citation:
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PMID: 20643186 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of the study was to investigate neuronal processing during the encoding, retention and retrieval phases of a serial visual working memory task. Particularly, we were interested in how these phases are affected by working memory load and how processing is modulated by methylphenidate. Healthy adults were asked to memorize the order of four, five or six pictures under methylphenidate (20mg) and under placebo while brain electrical activity was recorded. On the performance level, the number of correct responses decreased with increasing working memory load. Concerning brain electrical activity, in the encoding phase P3 amplitudes increased at midline electrodes with increasing memory load while load had no effect in the retention and retrieval phase. Medication neither influenced performance nor the different processing stages significantly. Our data provide evidence that during the encoding phase more attentional resources are allocated in trials with higher load as reflected by larger P3 amplitudes. |
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Authors:
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Petra Studer; Susanne Wangler; Martin S Diruf; Oliver Kratz; Gunther H Moll; Hartmut Heinrich |
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Publication Detail:
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Type: Journal Article Date: 2010-07-17 |
Journal Detail:
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Title: Neuroscience letters Volume: 482 ISSN: 1872-7972 ISO Abbreviation: Neurosci. Lett. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-20 Completed Date: 2010-12-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 172-6 Citation Subset: IM |
Copyright Information:
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(c) 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Child and Adolescent Mental Health, University of Erlangen-Nürnberg, Schwabachanlage 6, 91054 Erlangen, Germany. petra.studer@uk-erlangen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic Uptake Inhibitors
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pharmacology* Adult Brain / drug effects, physiology Dopamine Uptake Inhibitors / pharmacology* Electroencephalography Evoked Potentials, Visual / drug effects* Female Humans Male Memory, Short-Term / drug effects* Mental Recall / drug effects Methylphenidate / pharmacology* Retention (Psychology) / drug effects Serial Learning / drug effects* Visual Perception / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic Uptake Inhibitors; 0/Dopamine Uptake Inhibitors; 113-45-1/Methylphenidate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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