| The ERG responses to light stimuli of melanopsin-expressing retinal ganglion cells that are independent of rods and cones. | |
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MedLine Citation:
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PMID: 20685380 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The mechanisms by which melanopsin-expressing retinal ganglion cells (mRGCs) regulate circadian rhythms in humans have not been established. To understand mRGC characteristics and their role independent of effects due to the rods and cones, mRGC responses should be induced or measured independent of cone and rod responses. In the present study, we obtained results from light stimuli which differentially induce only the mRGC response by using a receptor-silent substitution technique. The mRGCs responded linearly to contrast changes of light stimuli, whereas they showed complicated responses to frequency changes with regard to the latency of response time. These results suggest that mRGC behavior is not a simple response to the various frequencies found in solar light but may be related to intrinsic neural circuits with feedback connections in the mRGC pathway. The results in this study demonstrated also that the test stimuli affected only the mRGC response and that this could be successfully detected by using the electroretinogram (ERG). |
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Authors:
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Yumi Fukuda; Sei-Ichi Tsujimura; Shigekazu Higuchi; Akira Yasukouchi; Takeshi Morita |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-6-2 |
Journal Detail:
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Title: Neuroscience letters Volume: - ISSN: 1872-7972 ISO Abbreviation: - Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-8-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2010. Published by Elsevier Ireland Ltd. |
Affiliation:
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Department of Living Environmental Science, Fukuoka Women's University, Fukuoka, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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