| ERG components of negative polarity from the inner retina and the optic nerve response. | |
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MedLine Citation:
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PMID: 16523235 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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ERG components of negative polarity in the light-adapted and in the dark-adapted inner retina are reviewed from a clinical perspective and include consideration of experimental research. Field potentials are inherently complex including summating contributions from specialized neurons as well as from glial elements. This property applies to the PERG, PhNR and to the STR. Experimental research can contribute to identifying the sites/cells of origins i.e. by determining depth profiles and by pharmacological manipulation. Intraretinal microelectrode-studies and pharmacological dissection of light-evoked responses have elucidated the origin of field potentials from the retinal pigment epithelium to the retinal ganglion cells. Thresholds for dark-adapted response components have been compared. Attenuation of the STR by anesthesia was found in cats in vivo when compared to threshold intensities used in isolated eye preparations in vitro, suggestive of depression of inner retinal activity by anesthetics. Evidence has been presented for antidromically elicited retinal responses of negative polarity that resemble the STR and summate with the light-evoked retinal response. This observation supports the notion that negative field potentials and components as recorded in the vitreous and at the cornea receive contributions from retinal ganglion cells. The weight of this contribution appears to vary among species, at least concerning the STR. The ocular negative responses from the inner retina are compared to cortical excitatory mechanisms generating negativity in the baseline of the EEG. |
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Authors:
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Günter Niemeyer |
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Publication Detail:
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Type: Journal Article; Review Date: 2006-03-06 |
Journal Detail:
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Title: Documenta ophthalmologica. Advances in ophthalmology Volume: 111 ISSN: 0012-4486 ISO Abbreviation: Doc Ophthalmol Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2006-03-08 Completed Date: 2006-07-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370667 Medline TA: Doc Ophthalmol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 179-89 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, University Hospital Zurich, Wissmannstr.16, CH-8057, Zurich, Switzerland. niemeyer@opht.unizh.ch |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dark Adaptation / physiology Electroretinography / methods Humans Optic Nerve / physiology* Photic Stimulation Retina / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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