Document Detail


ER stress and autophagy contribute to CsA-induced death of malignant glioma cells.
MedLine Citation:
PMID:  22910018     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Cyclosporine A (CsA), which revolutionized transplantology due to its ability to block the activation of lymphocytes and other immune system cells, triggers autophagy in malignant glioma cell lines via stimulation of endoplasmic reticulum (ER) stress. We also found that autophagy serves as a protective mechanism against CsA toxicity.
Authors:
Iwona Anna Ciechomska; Bozena Kaminska
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-01
Journal Detail:
Title:  Autophagy     Volume:  8     ISSN:  1554-8635     ISO Abbreviation:  Autophagy     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-8-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101265188     Medline TA:  Autophagy     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Laboratory of Transcription Regulation; Department of Cell Biology; Nencki Institute of Experimental Biology; Warsaw, Poland.
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