Document Detail


EPR spectroscopy and theoretical study of gamma-irradiated asparagine and aspartic acid in solid state.
MedLine Citation:
PMID:  16887255     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Aspartic acid (Asp) and asparagine (Asn) are vulnerable amino acids. One-electron addition or withdrawal reactions initiate many deleterious processes involving these amino acids. To study these redox processes we have irradiated by gamma-rays asparagine or aspartic acid in the solid state. The nature of the resulting free radicals was determined by electron paramagnetic resonance (EPR) and by calculations using DFT methods in various environments. Reactions initiated by electron transfer are different for both amino acids: Asn anion loses hydrogen atom whereas the cation undergoes decarboxylation. Conversely, Asp cation loses hydrogen atom from amine group, which triggers decarboxylation.
Authors:
Grazyna Strzelczak; Jacqueline Bergès; Chantal Houée-Levin; Dariusz Pogocki; Krzysztof Bobrowski
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-07-11
Journal Detail:
Title:  Biophysical chemistry     Volume:  125     ISSN:  0301-4622     ISO Abbreviation:  Biophys. Chem.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-11-14     Completed Date:  2007-02-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0403171     Medline TA:  Biophys Chem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  92-103     Citation Subset:  IM    
Affiliation:
Institute of Nuclear Chemistry and Technology, 03-195 Warsaw, Poland.
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MeSH Terms
Descriptor/Qualifier:
Asparagine / chemistry,  radiation effects*
Aspartic Acid / chemistry,  radiation effects*
Decarboxylation
Electron Spin Resonance Spectroscopy
Free Radicals / chemistry
Gamma Rays
Molecular Conformation / radiation effects
Chemical
Reg. No./Substance:
0/Free Radicals; 56-84-8/Aspartic Acid; 7006-34-0/Asparagine

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