| Epithelial Na+ channel (ENaC), hormones, and hypertension. | |
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MedLine Citation:
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PMID: 20460373 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This minireview examines both the basic science and clinical observations over the past 20 years to show how and why overstimulation of the amiloride-sensitive epithelial Na(+) channel (ENaC) expressed by epithelial principal cells of the renal collecting duct may be responsible for a large portion of hypertension in modern society. This idea is based on the finding that, in Liddle syndrome, a mutation of the beta- and/or gamma-subunits of ENaC produces an activated ion channel, in turn resulting in severe hypertension that is resistant to most forms of conventional antihypertensive therapy. ENaC can also be stimulated to conduct sodium by two hormones: aldosterone and insulin. These hormones are both often elevated in obese individuals with therapy-resistant hypertension. Thus, overstimulation of ENaC by metabolic abnormalities in obese individuals may be a likely cause of the hypertension that accompanies obesity. The molecular mechanisms underlying both Liddle syndrome and obesity-related hypertension are different (i.e. genetic and hormonal, respectively), but both have the same end result, namely increased ENaC activity. |
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Authors:
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James K Bubien |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-05-11 |
Journal Detail:
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Title: The Journal of biological chemistry Volume: 285 ISSN: 1083-351X ISO Abbreviation: J. Biol. Chem. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-26 Completed Date: 2010-09-14 Revised Date: 2011-08-02 |
Medline Journal Info:
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Nlm Unique ID: 2985121R Medline TA: J Biol Chem Country: United States |
Other Details:
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Languages: eng Pagination: 23527-31 Citation Subset: IM |
Affiliation:
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Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, AL 35294, USA. jbubien@bellsouth.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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metabolism Animals Antihypertensive Agents / pharmacology Epithelial Sodium Channel / chemistry* Genomics Hormones / metabolism* Humans Hypertension / metabolism* Insulin / metabolism Kidney / metabolism Mice Models, Biological Nitric Oxide / metabolism Obesity / metabolism Potassium Channels / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Epithelial Sodium Channel; 0/Hormones; 0/Potassium Channels; 10102-43-9/Nitric Oxide; 11061-68-0/Insulin; 52-39-1/Aldosterone |
| Comments/Corrections | |
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