Document Detail


EMT: when epithelial cells decide to become mesenchymal-like cells.
MedLine Citation:
PMID:  19487817     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Epithelial-mesenchymal transition (EMT) is critical for appropriate embryonic development, and this process is re-engaged in adults during wound healing, tissue regeneration, organ fibrosis, and cancer progression. Inflammation is a crucial conspirator in the emergence of EMT in adults but is absent during embryonic development. As highlighted in this Review series, EMT is now a recognized mechanism for dispersing cells in embryos, forming fibroblasts/mesenchymal cells in injured tissues, and initiating metastasis of epithelial cancer cells. Also discussed are proposals to classify EMT into three subtypes, each of which has different functional consequences.
Authors:
Raghu Kalluri
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  119     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-02     Completed Date:  2009-07-24     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1417-9     Citation Subset:  AIM; IM    
Affiliation:
Division of Matrix Biology, Beth Israel Deaconess Medical Center, and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02215, USA. rkalluri@bidmc.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation*
Disease
Epithelial Cells / cytology*
Health
Humans
Mesenchymal Stromal Cells / cytology*
Grant Support
ID/Acronym/Agency:
AA13913/AA/NIAAA NIH HHS; CA125550/CA/NCI NIH HHS; DK55001/DK/NIDDK NIH HHS; DK61688/DK/NIDDK NIH HHS; DK62978/DK/NIDDK NIH HHS
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