Document Detail

An ELISA technique for the measurement of C1q in cerebrospinal fluid.
MedLine Citation:
PMID:  3141513     Owner:  NLM     Status:  MEDLINE    
Determination of the C1q content of cerebrospinal fluid (CSF) may be of value in understanding the immunological reactions occurring within the central nervous system (CNS). A double sandwich ELISA method has been developed for the detection of C1q in human serum and CSF. It uses polyclonal antibodies and is sensitive in the nanogram range. The mean concentrations of C1q were determined to be 127 micrograms/ml in serum and 0.4 microgram/ml in CSF. These results suggest that increased levels of C1q in the CSF play a role in some neurodegenerative disorders.
C Delamarche; F Berger; A Pouplard; J Emile
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of immunological methods     Volume:  114     ISSN:  0022-1759     ISO Abbreviation:  J. Immunol. Methods     Publication Date:  1988 Nov 
Date Detail:
Created Date:  1988-12-19     Completed Date:  1988-12-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1305440     Medline TA:  J Immunol Methods     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  101-6     Citation Subset:  IM    
INSERM U 298, University Hospital, Angers, France.
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MeSH Terms
Alzheimer Disease / blood,  cerebrospinal fluid
Amyotrophic Lateral Sclerosis / blood,  cerebrospinal fluid
Complement Activating Enzymes / analysis,  cerebrospinal fluid*,  standards
Complement C1 / analysis,  cerebrospinal fluid*,  standards
Complement C1q
Enzyme-Linked Immunosorbent Assay* / standards
Middle Aged
Reference Standards
Reg. No./Substance:
0/Complement C1; 80295-33-6/Complement C1q; EC 3.-/Complement Activating Enzymes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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