Document Detail


An ELISA for IgA-IgG and IgM-RF measurement. II. RF in several disease and control groups and under gold therapy in RA.
MedLine Citation:
PMID:  3238359     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The before introduced solid phase ELISA was employed for the RF determination in the sera of RA patients and controls. The threshold values for positive results (calculated as the 95% distribution percentile of healthy donors) were 8, 3, and 3 U/ml for IgA, IgG, and IgM-RF, respectively. The results confirm the validity of the assay with clear negative results in several negative control groups (healthy donors, patients of the oto-, rhino-, laryngeal ambulance, diabetes mellitus, degenerative arthropathies; n = 111, median IgA, IgG and IgM-RF values of less than or equal to 2, less than or equal to 2 and less than or equal to 1 U/ml, respectively; 25-75% distribution percentiles within the median value) and positive results in the positive control group (seropositive RA; n = 20, median IgA, IgG and IgM-RF values of 324, 479 and 170 U/ml, respectively). 16/24 patients with so-called seronegative RA (negative Latex Fixation Test or Waaler Rose Test) had positive results in the ELISA, two of them had rheumatoid nodules clinically. The IgG-RF activity in the ELISA appears to be a good parameter for the course control of RA under gold therapy. 10 RA patients with clinical improvement of disease (declining ESR, CRP, joint index) after six months of gold therapy (= 0.6 g total gold amount) had a decline of total RF activity of 70% in median, whereas 10 patients with no clear effect on disease activity had only a decline of 20% in median.
Authors:
G Lemm; S Ruschen; H Warnatz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of rheumatology. Supplement     Volume:  75     ISSN:  0301-3847     ISO Abbreviation:  Scand. J. Rheumatol. Suppl.     Publication Date:  1988  
Date Detail:
Created Date:  1989-05-11     Completed Date:  1989-05-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0400360     Medline TA:  Scand J Rheumatol Suppl     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  256-60     Citation Subset:  IM    
Affiliation:
Department of Rheumatology and Clinical Immunology, Katholisches Krankenhaus Essen-Werden, FRG.
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MeSH Terms
Descriptor/Qualifier:
Arthritis, Rheumatoid / blood*,  drug therapy
Blood Sedimentation
C-Reactive Protein / analysis
Enzyme-Linked Immunosorbent Assay / methods*
Gold / therapeutic use
Humans
Immunoglobulin A / analysis*,  immunology
Immunoglobulin G / analysis*,  immunology
Immunoglobulin M / analysis*,  immunology
Rheumatoid Factor / analysis*
Chemical
Reg. No./Substance:
0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin M; 7440-57-5/Gold; 9007-41-4/C-Reactive Protein; 9009-79-4/Rheumatoid Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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