Document Detail

An ELISA for IgA-IgG and IgM-RF measurement. II. RF in several disease and control groups and under gold therapy in RA.
MedLine Citation:
PMID:  3238359     Owner:  NLM     Status:  MEDLINE    
The before introduced solid phase ELISA was employed for the RF determination in the sera of RA patients and controls. The threshold values for positive results (calculated as the 95% distribution percentile of healthy donors) were 8, 3, and 3 U/ml for IgA, IgG, and IgM-RF, respectively. The results confirm the validity of the assay with clear negative results in several negative control groups (healthy donors, patients of the oto-, rhino-, laryngeal ambulance, diabetes mellitus, degenerative arthropathies; n = 111, median IgA, IgG and IgM-RF values of less than or equal to 2, less than or equal to 2 and less than or equal to 1 U/ml, respectively; 25-75% distribution percentiles within the median value) and positive results in the positive control group (seropositive RA; n = 20, median IgA, IgG and IgM-RF values of 324, 479 and 170 U/ml, respectively). 16/24 patients with so-called seronegative RA (negative Latex Fixation Test or Waaler Rose Test) had positive results in the ELISA, two of them had rheumatoid nodules clinically. The IgG-RF activity in the ELISA appears to be a good parameter for the course control of RA under gold therapy. 10 RA patients with clinical improvement of disease (declining ESR, CRP, joint index) after six months of gold therapy (= 0.6 g total gold amount) had a decline of total RF activity of 70% in median, whereas 10 patients with no clear effect on disease activity had only a decline of 20% in median.
G Lemm; S Ruschen; H Warnatz
Related Documents :
7839069 - Defective mitogen-induced cellular cytotoxicity in untreated patients with active rheum...
20725879 - [cartilage quality in finger joints: delayed gd(dtpa)²-enhanced mri of the cartilage (d...
23662609 - Detection of brain amyloid β deposition in patients with neuropsychological impairment ...
19892679 - Rheumatoid arthritis-associated interstitial lung disease: the relevance of histopathol...
20422909 - Cardiac autonomic dysfunction in patients with systemic lupus, rheumatoid arthritis and...
7540479 - Levels of circulating intercellular adhesion molecule-1 and -3 but not circulating endo...
8478879 - A simple index to assess disease activity in rheumatoid arthritis.
2425529 - Effect of somatostatin on hyperamylasemia following endoscopic pancreatography.
20555049 - Clinical characteristics of people with head nodding in southern tanzania.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of rheumatology. Supplement     Volume:  75     ISSN:  0301-3847     ISO Abbreviation:  Scand. J. Rheumatol. Suppl.     Publication Date:  1988  
Date Detail:
Created Date:  1989-05-11     Completed Date:  1989-05-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0400360     Medline TA:  Scand J Rheumatol Suppl     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  256-60     Citation Subset:  IM    
Department of Rheumatology and Clinical Immunology, Katholisches Krankenhaus Essen-Werden, FRG.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Arthritis, Rheumatoid / blood*,  drug therapy
Blood Sedimentation
C-Reactive Protein / analysis
Enzyme-Linked Immunosorbent Assay / methods*
Gold / therapeutic use
Immunoglobulin A / analysis*,  immunology
Immunoglobulin G / analysis*,  immunology
Immunoglobulin M / analysis*,  immunology
Rheumatoid Factor / analysis*
Reg. No./Substance:
0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin M; 7440-57-5/Gold; 9007-41-4/C-Reactive Protein; 9009-79-4/Rheumatoid Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Relation between bone erosions and rheumatoid factor IgA and IgM isotypes in recent onset rheumatoid...
Next Document:  Waaler Rose titres may decrease but increase again during chrysotherapy.