Document Detail

EIF4E over-expresses and enhances cell proliferation and cell cycle progression in nasopharyngeal carcinoma.
MedLine Citation:
PMID:  23277284     Owner:  NLM     Status:  In-Data-Review    
Eukaryotic translation initiation factor 4E (eIF4E) is involved in integration and amplification of many carcinogenesis signals in tumors. However, it remains unclear whether eIF4E over-expresses in NPC and whether it is associated with the development of NPC. Here, we analyzed the expression state of eIF4E, c-Myc, and MMP9 in 24 nasopharyngitises and 64 nasopharyngeal carcinomas (NPC) tissues and studied the influences of eIF4E on the proliferation and cell cycle in NPC cell lines. The results indicate that eIF4E might over-express in NPC and the over-expression of eIF4E promotes NPC growth and cell cycle progression through enhancing the translational expression of c-Myc and MMP9. The finding certainly adds new knowledge in the understanding of the carcinogenesis of NPC and provides a potential molecular target for the NPC therapy and prevention.
Mengyan Wu; Yingxia Liu; Xiaoqing Di; Haixian Kang; Hua Zeng; Yi Zhao; Kangrong Cai; Tianyun Pang; Sen Wang; Yunhong Yao; Xinrong Hu
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Publication Detail:
Type:  Journal Article     Date:  2013-01-01
Journal Detail:
Title:  Medical oncology (Northwood, London, England)     Volume:  30     ISSN:  1559-131X     ISO Abbreviation:  Med. Oncol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-01-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9435512     Medline TA:  Med Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  400     Citation Subset:  IM    
Cancer Institute of Guangdong Medical College, No. 1 Xincheng Road, Dongguan, Guangdong Province, 523808, People's Republic of China.
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