| EGFR-mediated cell cycle regulation. | |
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MedLine Citation:
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PMID: 12017269 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cancer is a disease of uncontrolled cell proliferation. The cell cycle provides a crucial platform for coordination between proliferation and cell death. Somatic cells undergo replication and division by traversing the tightly regulated cell cycle. Growth factors play a critical role in initiating signaling events stimulating cell cycle progression, which is crucial for their mitogenic and tumorigenic effects. Epidermal growth factor receptor (EGFR) and its ligands are frequently upregulated in human cancers. The oncogenic effects of EGFR include initiation of DNA synthesis, enhanced cell growth, invasion, and metastasis. Specific abrogation of EGFR results in cell cycle arrest, apoptosis, or dedifferentiaton of cancer cells. Downregulation of EGFR signaling has therapeutic benefit in preclinical and clinical studies. Therefore, better understanding of the mechanisms of regulation and coordination between the cell cycle, cell growth, and cell death will lead to the development of novel cancer therapies. |
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Authors:
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Vivian Wai Yan Lui; Jennifer Rubin Grandis |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Anticancer research Volume: 22 ISSN: 0250-7005 ISO Abbreviation: Anticancer Res. Publication Date: 2002 Jan-Feb |
Date Detail:
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Created Date: 2002-05-17 Completed Date: 2002-06-25 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
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Languages: eng Pagination: 1-11 Citation Subset: IM |
Affiliation:
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Departments of Otolaryngology and Pharmacology, University of Pittsburg School of Medicine, PA 15213, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle / genetics, physiology* Genes, erbB-1 / physiology Humans Neoplasms / genetics, pathology* Receptor, Epidermal Growth Factor / genetics, physiology* Signal Transduction / genetics, physiology |
| Chemical | |
Reg. No./Substance:
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EC 2.7.10.1/Receptor, Epidermal Growth Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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