Document Detail

EGFR autocrine signaling in a compliant interstitial space: mechanotransduction from the outside in.
MedLine Citation:
PMID:  15254423     Owner:  NLM     Status:  MEDLINE    
Cells transduce mechanical forces into biochemical signals; traditionally these processes are thought to occur through direct effects on the cell membrane, the cytoskeleton, or specific transmembrane proteins. In multicellular tissues mechanical forces alter intercellular spacing through redistribution of interstitial fluid. Recent morphological and biochemical observations, bolstered by analytical modeling, support a new paradigm for mechanotransduction arising from constitutive growth factor shedding into a dynamically regulated interstitial volume.
Daniel J Tschumperlin
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Publication Detail:
Type:  Journal Article; Review     Date:  2004-08-25
Journal Detail:
Title:  Cell cycle (Georgetown, Tex.)     Volume:  3     ISSN:  1551-4005     ISO Abbreviation:  Cell Cycle     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-10-19     Completed Date:  2005-10-04     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  101137841     Medline TA:  Cell Cycle     Country:  United States    
Other Details:
Languages:  eng     Pagination:  996-7     Citation Subset:  IM    
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA.
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MeSH Terms
Autocrine Communication / physiology*
Extracellular Fluid / physiology*
Mechanotransduction, Cellular / physiology*
Receptor, Epidermal Growth Factor / physiology*
Reg. No./Substance:
EC, Epidermal Growth Factor

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