Document Detail

The EGF receptor defines domains of cell cycle progression and survival to regulate cell number in the developing Drosophila eye.
MedLine Citation:
PMID:  11257224     Owner:  NLM     Status:  MEDLINE    
The number of cells in developing organs must be controlled spatially by extracellular signals. Our results show how cell number can be regulated by cell interactions controlling proliferation and survival in local neighborhoods in the case of the Drosophila compound eye. Intercellular signals act during the second mitotic wave, a cell cycle that generates a pool of uncommitted cells used for most ommatidial fates. We find that G1/S progression to start the cell cycle requires EGF receptor inactivity. EGF receptor activation is then required for progression from G2 to M phase of the same cells, and also prevents apoptosis. EGF receptor activation depends on short-range signals from five-cell preclusters of photoreceptor neurons not participating in the second mitotic wave. Through proliferation and survival control, such signals couple the total number of uncommitted cells being generated to the neural patterning of the retina.
N E Baker; S Y Yu
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cell     Volume:  104     ISSN:  0092-8674     ISO Abbreviation:  Cell     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-03-21     Completed Date:  2001-04-05     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  699-708     Citation Subset:  IM    
Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
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MeSH Terms
Cell Count
Cell Cycle Proteins
Cell Survival / physiology
Drosophila / embryology*
Drosophila Proteins*
Epidermal Growth Factor*
Eye / cytology,  embryology
G1 Phase / physiology
G2 Phase / physiology
Gene Expression Regulation, Developmental
Membrane Proteins / genetics,  metabolism
Mitosis / physiology*
Phosphoprotein Phosphatases / genetics,  metabolism
Protein Tyrosine Phosphatases*
Receptor, Epidermal Growth Factor / genetics*,  metabolism*
cdc25 Phosphatases / genetics,  metabolism
Grant Support
Reg. No./Substance:
0/Cell Cycle Proteins; 0/Drosophila Proteins; 0/Membrane Proteins; 148175-53-5/spi protein, Drosophila; 62229-50-9/Epidermal Growth Factor; EC, Epidermal Growth Factor; EC Phosphatases; EC Tyrosine Phosphatases; EC Phosphatases; EC protein, Drosophila

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