Document Detail

EGF-like growth factors as mediators of LH action in the ovulatory follicle.
MedLine Citation:
PMID:  14726596     Owner:  NLM     Status:  MEDLINE    
Before ovulation in mammals, a cascade of events resembling an inflammatory and/or tissue remodeling process is triggered by luteinizing hormone (LH) in the ovarian follicle. Many LH effects, however, are thought to be indirect because of the restricted expression of its receptor. Here, we demonstrate that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epiregulin, and beta-cellulin. Incubation of follicles with these growth factors recapitulates the morphological and biochemical events triggered by LH, including cumulus expansion and oocyte maturation. Thus, these EGF-related growth factors are paracrine mediators that propagate the LH signal throughout the follicle.
Jy-Young Park; You-Qiang Su; Miyako Ariga; Evelyn Law; S-L Catherine Jin; Marco Conti
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.     Date:  2004-01-15
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  303     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-01-30     Completed Date:  2004-02-20     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  682-4     Citation Subset:  IM    
Division of Reproductive Biology and Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305, USA.
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MeSH Terms
Chorionic Gonadotropin / pharmacology
Epidermal Growth Factor / genetics,  metabolism*
Gene Expression Regulation
Glycoproteins / genetics,  metabolism*
Granulosa Cells / metabolism
Intercellular Signaling Peptides and Proteins / genetics,  metabolism*
Luteinizing Hormone / pharmacology,  physiology*
Mice, Inbred C57BL
Oocytes / physiology
Organ Culture Techniques
Ovarian Follicle / physiology*
Ovulation / physiology*
Paracrine Communication
RNA, Messenger / genetics,  metabolism
Receptor, Epidermal Growth Factor / metabolism
Signal Transduction
Grant Support
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Glycoproteins; 0/Intercellular Signaling Peptides and Proteins; 0/RNA, Messenger; 0/betacellulin; 0/epiregulin; 117147-70-3/amphiregulin; 62229-50-9/Epidermal Growth Factor; 9002-67-9/Luteinizing Hormone; EC, Epidermal Growth Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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