Document Detail


EG-VEGF: a key endocrine factor in placental development.
MedLine Citation:
PMID:  22709436     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Endocrine gland-derived vascular endothelial growth factor (EG-VEGF), also named prokineticin 1, is the canonical member of the prokineticin family. Numerous reports suggest a direct involvement of this peptide in normal and pathological reproductive processes. Recent advances propose EG-VEGF as a key endocrine factor that controls many aspects of placental development and suggest its involvement in the development of preeclampsia (PE), the most threatening pathology of human pregnancy. This review describes the finely tuned action and regulation of EG-VEGF throughout human pregnancy, argues for its clinical relevance as a potential diagnostic marker of the onset of PE, and discusses future research directions for therapeutic targeting of EG-VEGF.
Authors:
Sophie Brouillet; Pascale Hoffmann; Jean-Jacques Feige; Nadia Alfaidy
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-16
Journal Detail:
Title:  Trends in endocrinology and metabolism: TEM     Volume:  -     ISSN:  1879-3061     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9001516     Medline TA:  Trends Endocrinol Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Institut National de la Santé et de la Recherche Médicale (INSERM), Unité 1036, Grenoble, France; Commissariat à l'Energie Atomique, Institut de Recherches en Technologies et Sciences pour le Vivant (iRTSV)-Biologie du Cancer et de l'Infection (BCI), Grenoble, France; Université Joseph Fourier, Grenoble 1, France.
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