Document Detail

EF hand-mediated Ca- and cGMP-signaling in photoreceptor synaptic terminals.
MedLine Citation:
PMID:  22393316     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Photoreceptors, the light-sensitive receptor neurons of the retina, receive and transmit a plethora of visual informations from the surrounding world. Photoreceptors capture light and convert this energy into electrical signals that are conveyed to the inner retina. For synaptic communication with the inner retina, photoreceptors make large active zones that are marked by synaptic ribbons. These unique synapses support continuous vesicle exocytosis that is modulated by light-induced, graded changes of membrane potential. Synaptic transmission can be adjusted in an activity-dependent manner, and at the synaptic ribbons, Ca(2+)- and cGMP-dependent processes appear to play a central role. EF-hand-containing proteins mediate many of these Ca(2+)- and cGMP-dependent functions. Since continuous signaling of photoreceptors appears to be prone to malfunction, disturbances of Ca(2+)- and cGMP-mediated signaling in photoreceptors can lead to visual defects, retinal degeneration (rd), and even blindness. This review summarizes aspects of signal transmission at the photoreceptor presynaptic terminals that involve EF-hand-containing Ca(2+)-binding proteins.
Frank Schmitz; Sivaraman Natarajan; Jagadeesh K Venkatesan; Silke Wahl; Karin Schwarz; Chad P Grabner
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Publication Detail:
Type:  Journal Article     Date:  2012-02-29
Journal Detail:
Title:  Frontiers in molecular neuroscience     Volume:  5     ISSN:  1662-5099     ISO Abbreviation:  Front Mol Neurosci     Publication Date:  2012  
Date Detail:
Created Date:  2012-03-06     Completed Date:  2012-10-02     Revised Date:  2013-08-13    
Medline Journal Info:
Nlm Unique ID:  101477914     Medline TA:  Front Mol Neurosci     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  26     Citation Subset:  -    
Department of Neuroanatomy, Medical School Homburg/Saar, Institute for Anatomy and Cell Biology, Saarland University Saarland, Germany.
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