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EEG frequency during spike-wave discharges may predict treatment outcome in patients with idiopathic generalized epilepsies.
MedLine Citation:
PMID:  21453359     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We report findings concerning the relationship between electroencephalography (EEG) frequency during spike-and-wave discharges (SWDs) and response to treatment in 21 patients with idiopathic generalized epilepsy (IGE). We studied patients whose EEG contained SWDs lasting at least 4 s. Among these patients, two groups could be distinguished on the basis of a subtle difference in EEG frequency during the first 2 s of the burst. The two groups differed markedly in their clinical response to medication, with the group becoming seizure-free during the next 1-2 years showing a spike-wave onset frequency of >3.2 Hz, and those not seizure-free <3.2 Hz (p = 0.0034, sensitivity 75% and specificity 92%). Given this strong effect in a relatively small group, further work is needed to clarify the predictive value of this frequency measure for clinical outcomes in absence epilepsies.
Authors:
Oscar Benjamin; Patrick Colvin; Moses Kibuuka; Gonzalo Alarcón; Mark P Richardson; John R Terry
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-31
Journal Detail:
Title:  Epilepsia     Volume:  -     ISSN:  1528-1167     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-4-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Wiley Periodicals, Inc. © 2011 International League Against Epilepsy.
Affiliation:
Department of Engineering Mathematics, University of Bristol, Bristol, United Kingdom Institute of Psychiatry, King's College London, London, United Kingdom Department of Automatic Control and Systems Engineering, University of Sheffield, Sheffield, United Kingdom Sheffield Institute for Translational Neuroscience, University of Sheffield, United Kingdom.
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