| EEG-fMRI reveals activation of brainstem and thalamus in patients with Lennox-Gastaut syndrome. | |
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MedLine Citation:
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PMID: 21275978 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Purpose: Even if etiologies of Lennox-Gastaut syndrome (LGS) are diverse, the multiple causes converge into a final common pathway that results in this specific epilepsy phenotype. There is little knowledge, however, about neuronal networks that may be a part of this pathway. Methods: To investigate these networks, 11 children with LGS and 9 control children with multifocal epileptic activity were investigated using simultaneous recordings of EEG and functional MRI (EEG-fMRI) in a 3 Tesla scanner. Key Findings: Individual and group analyses revealed significant activation of brainstem and thalamus (especially centromedian and anterior thalamus) associated with epileptiform discharges in patients with LGS. None of the patients with multifocal epileptic activity presented with the same hemodynamic activation pattern. Significance: Because brainstem activation has been associated with infantile spasms, which often evolve into LGS, and thalamus activation has been observed in patients with primary (idiopathic generalized syndromes) and secondary (focal epilepsies) bilateral synchrony, the described network in LGS may represent the common pathogenetic pathway of these different conditions. |
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Authors:
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Michael Siniatchkin; Diana Coropceanu; Friederike Moeller; Rainer Boor; Ulrich Stephani |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-28 |
Journal Detail:
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Title: Epilepsia Volume: - ISSN: 1528-1167 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2983306R Medline TA: Epilepsia Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Wiley Periodicals, Inc. © 2011 International League Against Epilepsy. |
Affiliation:
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Department of Neuropediatrics, Christian-Albrechts-University, Kiel, Germany Northern German Epilepsy Center, Raisdorf, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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