Document Detail

EEG changes and serum anticholinergic activity measured in patients with delirium in the intensive care unit.
MedLine Citation:
PMID:  17991256     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to examine whether serum anticholinergic activity (SAA) is a reliable indicator of delirium in the ICU, and whether there is a significant correlation between SAA and quantitative electroencephalographic (EEG) data in delirious patients. In a prospective cohort study, we assessed ICU patients diagnosed with delirium (n = 37). EEG measurements and blood analysis including SAA were performed 48 h following ICU admission. The presence of delirium was evaluated using the Confusion Assessment Method for critically ill patients in ICU (CAM-ICU). The SAA level was measured using a competitive radioreceptor binding assay for muscarinergic receptors and quantitative EEG was measured using the CATEEM system. We found that, under comparable conditions, patients in the delirium group showed a higher relative EEG theta power and a reduced alpha power (n = 17) than did the non-delirious patients (n = 20). No difference in measured SAA levels were seen; therefore, there was no correlation between SAA and EEG measurements in delirious patients. We conclude that, in contrast to the EEG, the SAA level cannot be proposed as a tool for diagnosing delirium in ICU patients.
K Plaschke; H Hill; R Engelhardt; C Thomas; R von Haken; M Scholz; J Kopitz; H J Bardenheuer; M Weisbrod; M A Weigand
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anaesthesia     Volume:  62     ISSN:  1365-2044     ISO Abbreviation:  Anaesthesia     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-09     Completed Date:  2007-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  England    
Other Details:
Languages:  eng     Pagination:  1217-23     Citation Subset:  AIM; IM    
Department of Anaesthesiology, Medical Faculty of the University of Heidelberg, Germany.
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MeSH Terms
Biological Markers / blood
Cholinergic Antagonists / blood*
Delirium / blood,  diagnosis*
Intensive Care Units*
Middle Aged
Prospective Studies
Severity of Illness Index
Signal Processing, Computer-Assisted
Reg. No./Substance:
0/Biological Markers; 0/Cholinergic Antagonists

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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