| EEG changes and serum anticholinergic activity measured in patients with delirium in the intensive care unit. | |
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MedLine Citation:
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PMID: 17991256 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to examine whether serum anticholinergic activity (SAA) is a reliable indicator of delirium in the ICU, and whether there is a significant correlation between SAA and quantitative electroencephalographic (EEG) data in delirious patients. In a prospective cohort study, we assessed ICU patients diagnosed with delirium (n = 37). EEG measurements and blood analysis including SAA were performed 48 h following ICU admission. The presence of delirium was evaluated using the Confusion Assessment Method for critically ill patients in ICU (CAM-ICU). The SAA level was measured using a competitive radioreceptor binding assay for muscarinergic receptors and quantitative EEG was measured using the CATEEM system. We found that, under comparable conditions, patients in the delirium group showed a higher relative EEG theta power and a reduced alpha power (n = 17) than did the non-delirious patients (n = 20). No difference in measured SAA levels were seen; therefore, there was no correlation between SAA and EEG measurements in delirious patients. We conclude that, in contrast to the EEG, the SAA level cannot be proposed as a tool for diagnosing delirium in ICU patients. |
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Authors:
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K Plaschke; H Hill; R Engelhardt; C Thomas; R von Haken; M Scholz; J Kopitz; H J Bardenheuer; M Weisbrod; M A Weigand |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anaesthesia Volume: 62 ISSN: 1365-2044 ISO Abbreviation: Anaesthesia Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-11-09 Completed Date: 2007-12-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370524 Medline TA: Anaesthesia Country: England |
Other Details:
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Languages: eng Pagination: 1217-23 Citation Subset: AIM; IM |
Affiliation:
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Department of Anaesthesiology, Medical Faculty of the University of Heidelberg, Germany. konstanze.plaschke@med.uni-heidelberg.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Biological Markers / blood Cholinergic Antagonists / blood* Delirium / blood, diagnosis* Electroencephalography Female Humans Intensive Care Units* Male Middle Aged Prospective Studies Severity of Illness Index Signal Processing, Computer-Assisted |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Cholinergic Antagonists |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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