Document Detail


EEG and cardiac activation during periodic leg movements in sleep: support for a hierarchy of arousal responses.
MedLine Citation:
PMID:  10078729     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate other physiologic changes that occur with periodic leg movements during sleep (PLMS) that might be considered to be more sensitive indices of sleep fragmentation. BACKGROUND: Although PLMS are associated with recurrent microarousals (MA), the frequency of PLMS with MA does not correlate with objective daytime sleepiness. It is postulated that the lack of correlation results from the low sensitivity of the standard criteria used to score MA. METHODS: Ten drug-free patients with a polygraphic and clinical diagnosis of restless legs syndrome (RLS) and PLMS were examined. The EEG correlates of PLMS were analyzed by visual scoring and spectral analysis during PLMS that ended in a visible microarousal (PLMS with MA) or not (PLMS without MA). The R-R interval in the EKG signal was also examined. RESULTS: A total of 34% of PLMS were associated with MA lasting >3 seconds, and 3% of PLMS were associated with MA lasting <3 seconds. Although PLMS with MA were associated with an increase in alpha activity, for PLMS without MA a significant increase in delta and theta activity was present. Both types of PLMS induced a shortening of the R-R interval; this was particularly more marked for PLMS with MA. CONCLUSIONS: First, visual scoring of MA that include a duration of less than 3 seconds has little effect on the detection of PLMS with MA. Second, EEG activation and tachycardia are present during both types of PLMS. Third, a hierarchy in the arousal response is present-going from autonomic activation to bursts of delta activity to alpha activity to a full awakening.
Authors:
E Sforza; A Nicolas; G Lavigne; A Gosselin; D Petit; J Montplaisir
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurology     Volume:  52     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-04-30     Completed Date:  1999-04-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  786-91     Citation Subset:  AIM; IM; S    
Affiliation:
Service d'Explorations Fonctionnelles du Système Nerveux et de Pathologie du Sommeil, Hôpitaux Universitaires de Strasbourg, Université de Strasbourg, France.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Arousal / physiology*
Electroencephalography
Female
Heart Rate / physiology*
Humans
Leg / physiology*
Male
Middle Aged
Movement / physiology*
Restless Legs Syndrome / physiopathology*
Sleep / physiology*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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