| EEG abnormalities in early and late onset Alzheimer's disease: understanding heterogeneity. | |
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MedLine Citation:
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PMID: 20935323 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare differences in severity and type of electroencephalography (EEG) abnormalities between early and late onset Alzheimer's disease (AD) and to assess the influence of APOE genotype on this association, in order to understand the biological differences in AD according to age at onset METHOD: Of 460 probable AD patients and 336 patients with subjective complaints, serving as controls, EEG and APOE genotype were obtained. Subjects were categorised by age into a younger (≤65 years) and an older group (>65 years), based on age at diagnosis. Severity and type of EEG abnormalities were visually assessed. Severity of EEG abnormalities ranged from normal to slightly abnormal to moderately severe. EEG abnormalities were characterised as only focal abnormalities, only diffuse abnormalities or both focal and diffuse abnormalities. RESULTS: Logistic regression revealed that younger AD patients more often had EEG abnormalities, which were more severe, with a predominance of both focal and diffuse abnormalities. In controls, we observed the opposite, as older controls more often had EEG abnormalities than younger controls. Furthermore, APOE ε4 negative AD patients had more severe EEG abnormalities than APOE ε4 positive AD patients, while no such effect was observed in controls. There was no interaction between age at onset and APOE ε4 genotype. CONCLUSION: Early onset and APOE ε4 negative AD patients present with more severe EEG abnormalities than late onset and APOE ε4 positive AD patients. These results suggest that in younger patients, AD manifests with more prominent functional brain changes. |
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Authors:
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Hanneke de Waal; Cornelis J Stam; Marinus A Blankenstein; Yolande A L Pijnenburg; Philip Scheltens; Wiesje M van der Flier |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-09 |
Journal Detail:
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Title: Journal of neurology, neurosurgery, and psychiatry Volume: 82 ISSN: 1468-330X ISO Abbreviation: J. Neurol. Neurosurg. Psychiatr. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-14 Completed Date: 2011-01-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985191R Medline TA: J Neurol Neurosurg Psychiatry Country: England |
Other Details:
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Languages: eng Pagination: 67-71 Citation Subset: IM |
Affiliation:
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Alzheimer Center, Department of Neurology, VU University Medical Centre, Amsterdam, the Netherlands. h.dewaal@vumc.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age of Onset Aged Alzheimer Disease / genetics, physiopathology* Apolipoproteins E / genetics DNA / genetics Electroencephalography* Female Genotype Humans Individuality Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins E; 9007-49-2/DNA |
| Comments/Corrections | |
Comment In:
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J Neurol Neurosurg Psychiatry. 2011 Jan;82(1):2
[PMID:
20974650
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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