| EEG abnormalities before clozapine therapy predict a good clinical response to clozapine. | |
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MedLine Citation:
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PMID: 8743641 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to test the hypothesis that minor EEG abnormalities predict a favorable response to clozapine. Eighty-six psychotic clozapine-treated psychiatric inpatients with EEG records before starting clozapine were included in the study. When all diagnostic groups were combined, there were no significant differences in clinical outcome between patients with abnormal EEGs and patients with normal EEGs. However, female patients with abnormal EEGs had a significantly greater improvement in Global Assessment of Functioning (GAF) scores compared to female patients with normal EEGs. In addition, patients with major depressive episodes (bipolar, schizoaffective, unipolar) and abnormal EEGs had a significantly greater improvement in GAF scores compared to the same subgroup of patients with normal EEGs. The results suggest that EEG abnormalities before clozapine treatment many predict a favorable clinical response in specific groups of patients. |
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Authors:
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S S Pillay; A L Stoll; M K Weiss; M Tohen; C A Zarate; M D Banov; J O Cole |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists Volume: 8 ISSN: 1040-1237 ISO Abbreviation: Ann Clin Psychiatry Publication Date: 1996 Mar |
Date Detail:
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Created Date: 1996-11-07 Completed Date: 1996-11-07 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8911021 Medline TA: Ann Clin Psychiatry Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1-5 Citation Subset: IM |
Affiliation:
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Psychopharmacology Service, McLean Hospital, Belmont, Massachusetts 02178, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antipsychotic Agents / therapeutic use* Bipolar Disorder / drug therapy*, physiopathology Clozapine / therapeutic use* Depressive Disorder / drug therapy*, physiopathology Electroencephalography / drug effects* Female Humans Male Psychiatric Status Rating Scales Psychotic Disorders / drug therapy*, physiopathology Retrospective Studies Schizophrenia / drug therapy, physiopathology Sex Factors Single-Blind Method Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 5786-21-0/Clozapine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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