Document Detail

EEG abnormalities before clozapine therapy predict a good clinical response to clozapine.
MedLine Citation:
PMID:  8743641     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to test the hypothesis that minor EEG abnormalities predict a favorable response to clozapine. Eighty-six psychotic clozapine-treated psychiatric inpatients with EEG records before starting clozapine were included in the study. When all diagnostic groups were combined, there were no significant differences in clinical outcome between patients with abnormal EEGs and patients with normal EEGs. However, female patients with abnormal EEGs had a significantly greater improvement in Global Assessment of Functioning (GAF) scores compared to female patients with normal EEGs. In addition, patients with major depressive episodes (bipolar, schizoaffective, unipolar) and abnormal EEGs had a significantly greater improvement in GAF scores compared to the same subgroup of patients with normal EEGs. The results suggest that EEG abnormalities before clozapine treatment many predict a favorable clinical response in specific groups of patients.
S S Pillay; A L Stoll; M K Weiss; M Tohen; C A Zarate; M D Banov; J O Cole
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists     Volume:  8     ISSN:  1040-1237     ISO Abbreviation:  Ann Clin Psychiatry     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-11-07     Completed Date:  1996-11-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8911021     Medline TA:  Ann Clin Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-5     Citation Subset:  IM    
Psychopharmacology Service, McLean Hospital, Belmont, Massachusetts 02178, USA.
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MeSH Terms
Antipsychotic Agents / therapeutic use*
Bipolar Disorder / drug therapy*,  physiopathology
Clozapine / therapeutic use*
Depressive Disorder / drug therapy*,  physiopathology
Electroencephalography / drug effects*
Psychiatric Status Rating Scales
Psychotic Disorders / drug therapy*,  physiopathology
Retrospective Studies
Schizophrenia / drug therapy,  physiopathology
Sex Factors
Single-Blind Method
Treatment Outcome
Reg. No./Substance:
0/Antipsychotic Agents; 5786-21-0/Clozapine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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