Document Detail

EEG evidence of posterior cortical disconnection in PD and related dementias.
MedLine Citation:
PMID:  20199199     Owner:  NLM     Status:  MEDLINE    
Electroencephalogram (EEG) reactivity to eyes opening and 12-Hz photic stimulation was investigated in 14 healthy elderly subjects, 21 parkinsonian patients (PD), 7 demented parkinsonian patients (PDD), and 10 patients with Lewy body dementia (LBD) using global field synchronization (GFS). During eyes closed Theta GFS was increased in Parkinson's disease and patients and alpha1 GFS was decreased in LBD subjects. During 12-Hz intermittent photic stimulation (IPS), reactivity of posterior electrodes was decreased in PD and LBD patients. No reactivity was observed in PDD. Results are consistent with a graded posterior cortical disconnection in parkinsonian syndromes and with a model of dopamine-modulated thalamocortical interplay in visual processing.
Luigi Pugnetti; Francesca Baglio; Elisabetta Farina; Margherita Alberoni; Elena Calabrese; Antonio Gambini; Enrico Di Bella; Massimo Garegnani; Laura Deleonardis; Raffaello Nemni
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The International journal of neuroscience     Volume:  120     ISSN:  1563-5279     ISO Abbreviation:  Int. J. Neurosci.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-03-04     Completed Date:  2010-05-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0270707     Medline TA:  Int J Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  88-98     Citation Subset:  IM    
Scientific Institute S. Maria Nascente, Fondazione don C. Gnocchi, Milan, Italy.
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MeSH Terms
Aged, 80 and over
Alpha Rhythm
Brain / physiopathology
Cerebral Cortex / physiopathology*
Data Interpretation, Statistical
Dementia / etiology,  physiopathology*
Lewy Body Disease / physiopathology
Middle Aged
Parkinson Disease / complications,  physiopathology*
Photic Stimulation
Theta Rhythm

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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