| EDRF and norepinephrine-induced vasodilation in the canine coronary circulation. | |
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MedLine Citation:
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PMID: 7771547 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Experiments were performed to characterize the role of endothelium-derived relaxing factor (EDRF) in coronary vasodilation caused by norepinephrine. The circumflex or left anterior descending coronary artery was cannulated and pump perfused with constant pressure or constant flow in closed-chest anesthetized dogs. Prostaglandin synthesis was blocked with ibuprofen. During constant-pressure perfusion, EDRF inhibition with intracoronary N omega-nitro-L-arginine (L-NNA) did not affect the vasodilation due to nitroglycerin (an endothelium-independent process). However, L-NNA did significantly inhibit (P < 0.001) the vasodilation due to acetylcholine (an endothelium-dependent process). In response to bolus injections of norepinephrine, EDRF inhibition with L-NNA significantly reduced coronary vasodilation (P < 0.001). This inhibition was partially reversed with L-arginine infusion. To determine whether an increase in shear stress due to an increase in flow was the stimulus for EDRF release, experiments were performed during constant-flow conditions. Vasodilation caused by nitroglycerin was not inhibited by L-NNA, but EDRF inhibition did blunt acetylcholine-induced vasodilation significantly (P < 0.001) during constant-flow perfusion. During EDRF inhibition with L-NNA, vasodilation due to norepinephrine was not significantly altered when coronary flow was held constant (P = 0.19). In conclusion, EDRF plays a role in norepinephrine-induced coronary vasodilation that is largely flow dependent. |
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Authors:
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R Van Bibber; O Traub; K Kroll; E O Feigl |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 268 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1995 May |
Date Detail:
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Created Date: 1995-07-06 Completed Date: 1995-07-06 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H1973-81 Citation Subset: IM |
Affiliation:
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Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle 98195, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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pharmacology Animals Arginine / analogs & derivatives, pharmacology Blood Pressure / drug effects Coronary Circulation / drug effects*, physiology Dogs Dose-Response Relationship, Drug Female Male Nitric Oxide / antagonists & inhibitors, physiology* Nitroarginine Nitroglycerin / pharmacology Norepinephrine / pharmacology* Vasodilation* |
| Grant Support | |
ID/Acronym/Agency:
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HL-16910/HL/NHLBI NIH HHS; HL-49822/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide; 2149-70-4/Nitroarginine; 51-41-2/Norepinephrine; 51-84-3/Acetylcholine; 55-63-0/Nitroglycerin; 74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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