| EDIBLE: experimental design and information calculations in phylogenetics. | |
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MedLine Citation:
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PMID: 10869025 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although evolutionary inference from molecular sequences is a statistical problem, little attention has been paid to questions of experimental design. A computer program, EDIBLE, has been developed to perform likelihood calculations based on Markov process models of nucleotide substitution allied with phylogenetic trees, and from these to compute Fisher information measures under different experimental designs. These calculations can be used to answer questions of optimal experimental design in molecular phylogenetics. AVAILABILITY: Source code (ANSI C), executables and documentation for EDIBLE are available from http://ng-dec1.gen.cam. ac.uk/info/index.htmland 'downstream' Web pages. CONTACT: N.Goldman@gen.cam.ac.uk |
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Authors:
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T Massingham; N Goldman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Bioinformatics (Oxford, England) Volume: 16 ISSN: 1367-4803 ISO Abbreviation: Bioinformatics Publication Date: 2000 Mar |
Date Detail:
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Created Date: 2000-08-17 Completed Date: 2000-08-17 Revised Date: 2010-05-10 |
Medline Journal Info:
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Nlm Unique ID: 9808944 Medline TA: Bioinformatics Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 294-5 Citation Subset: IM |
Affiliation:
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Department of Genetics, Downing Street, Cambridge CB2 3EH, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Likelihood Functions Markov Chains Phylogeny* Software* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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