Document Detail

ECMO criteria for influenza A (H1N1)-associated ARDS: role of transpulmonary pressure.
MedLine Citation:
PMID:  22323077     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To assess whether partitioning the elastance of the respiratory system (E (RS)) between lung (E (L)) and chest wall (E (CW)) elastance in order to target values of end-inspiratory transpulmonary pressure (PPLAT(L)) close to its upper physiological limit (25 cmH(2)O) may optimize oxygenation allowing conventional treatment in patients with influenza A (H1N1)-associated ARDS referred for extracorporeal membrane oxygenation (ECMO).
METHODS: Prospective data collection of patients with influenza A (H1N1)-associated ARDS referred for ECMO (October 2009-January 2010). Esophageal pressure was used to (a) partition respiratory mechanics between lung and chest wall, (b) titrate positive end-expiratory pressure (PEEP) to target the upper physiological limit of PPLAT(L) (25 cmH(2)O).
RESULTS: Fourteen patients were referred for ECMO. In seven patients PPLAT(L) was 27.2 ± 1.2 cmH(2)O; all these patients underwent ECMO. In the other seven patients, PPLAT(L) was 16.6 ± 2.9 cmH(2)O. Raising PEEP (from 17.9 ± 1.2 to 22.3 ± 1.4 cmH(2)O, P = 0.0001) to approach the upper physiological limit of transpulmonary pressure (PPLAT(L) = 25.3 ± 1.7 cm H(2)O) improved oxygenation index (from 37.4 ± 3.7 to 16.5 ± 1.4, P = 0.0001) allowing patients to be treated with conventional ventilation.
CONCLUSIONS: Abnormalities of chest wall mechanics may be present in some patients with influenza A (H1N1)-associated ARDS. These abnormalities may not be inferred from measurements of end-inspiratory plateau pressure of the respiratory system (PPLAT(RS)). In these patients, titrating PEEP to PPLAT(RS) may overestimate the incidence of hypoxemia refractory to conventional ventilation leading to inappropriate use of ECMO.
Salvatore Grasso; Pierpaolo Terragni; Alberto Birocco; Rosario Urbino; Lorenzo Del Sorbo; Claudia Filippini; Luciana Mascia; Antonio Pesenti; Alberto Zangrillo; Luciano Gattinoni; V Marco Ranieri
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-02-10
Journal Detail:
Title:  Intensive care medicine     Volume:  38     ISSN:  1432-1238     ISO Abbreviation:  Intensive Care Med     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-27     Completed Date:  2012-06-21     Revised Date:  2012-08-10    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  395-403     Citation Subset:  IM    
Dipartimento dell'Emergenza e Trapianti d'Organo, Sezione di Anestesiologia e Rianimazione, Università degli Studi Aldo Moro, Bari, Italy.
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MeSH Terms
Extracorporeal Membrane Oxygenation / standards*
Influenza A Virus, H1N1 Subtype
Influenza, Human / complications*,  therapy
Positive-Pressure Respiration / methods,  standards*
Respiratory Distress Syndrome, Adult / etiology,  therapy*
Comment In:
Intensive Care Med. 2012 Jul;38(7):1241   [PMID:  22527061 ]
Intensive Care Med. 2012 Mar;38(3):339-41   [PMID:  22323078 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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