| ECM gene expression and its modulation by insulin in diabetic rats. | |
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MedLine Citation:
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PMID: 1280237 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The steady-state levels of mRNA encoding for the alpha 1(IV) collagen chain, laminin B1 and B2 chains, basement membrane HSPG, and alpha 1(I) and alpha 1(III) collagen chains were examined in rat glomeruli at 4, 12, and 24 wk after injection of STZ. The mRNA levels for the alpha 1(IV) collagen chain, laminin B1 and B2 chains, and alpha 1(I) and alpha 1(III) collagen chains increased significantly with age in the STZ-induced diabetic rats before morphological thickening of basement membrane occurred. In contrast, the mRNA levels for HSPG decreased markedly 4 wk after STZ injection and then increased with age compared with those for control rats. The mRNA levels for these ECM components showed a continuous decline with age in controls. Treating the diabetic rats with insulin for 4 wk ameliorated the abnormally regulated ECM gene expression in the glomeruli. These data suggest that the abnormal regulation of ECM gene expression in the glomeruli may contribute to the expansion of mesangial matrix and basement membrane thickening in diabetic rats, and that hyperglycemia may play a role in the abnormal ECM gene expression. |
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Authors:
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M Fukui; T Nakamura; I Ebihara; I Shirato; Y Tomino; H Koide |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Diabetes Volume: 41 ISSN: 0012-1797 ISO Abbreviation: Diabetes Publication Date: 1992 Dec |
Date Detail:
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Created Date: 1992-12-28 Completed Date: 1992-12-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372763 Medline TA: Diabetes Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1520-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Basement Membrane / drug effects, metabolism, ultrastructure Blotting, Northern Collagen / biosynthesis, genetics Diabetes Mellitus, Experimental / drug therapy, metabolism*, pathology Extracellular Matrix Proteins / biosynthesis, genetics* Gene Expression / drug effects Heparan Sulfate Proteoglycans Heparitin Sulfate / biosynthesis, genetics Insulin / pharmacology*, therapeutic use Kidney Glomerulus / drug effects, metabolism*, ultrastructure Laminin / biosynthesis, genetics Macromolecular Substances Male Microscopy, Electron Proteoglycans / biosynthesis, genetics RNA / genetics, isolation & purification RNA, Messenger / metabolism* Rats Rats, Sprague-Dawley Reference Values |
| Chemical | |
Reg. No./Substance:
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0/Extracellular Matrix Proteins; 0/Heparan Sulfate Proteoglycans; 0/Laminin; 0/Macromolecular Substances; 0/Proteoglycans; 0/RNA, Messenger; 11061-68-0/Insulin; 63231-63-0/RNA; 9007-34-5/Collagen; 9050-30-0/Heparitin Sulfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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