| ECHO parameters of diastolic dysfunction. | |
| | |
MedLine Citation:
|
PMID: 19346268 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Most patients with cardiac disease have diastolic dysfunction which is characterized by impaired diastolic filling and/or abnormal diastolic relaxation. The trans-esophageal echocardiography (TEE) used routinely during open-heart surgical procedures has exceptional resolution that may permit the identification and grading of diastolic dysfunction. The goal of this study was to determine which echocardiography (ECHO) parameters can best describe diastolic dysfunction due to myocardial remodeling and fibrosis. Baseline transthoracic ECHO was performed on 3-month-old C57BL/6J female mice followed by administration of isoproterenol (2 microg/g/d) for 6 days. On day 7, transthoracic ECHO was performed to determine the change of left ventricular (LV) inflow parameters due to isoproterenol-mediated cardiac remodeling. The mid-LV region was stained with picrosirius red to quantify myocardial fibrosis and demonstrated a 5-fold increase in cardiac fibrosis (p = 0.002). LV mass was increased by 36% (p = 0.0016). Mitral valve flow Doppler peak velocities E and A were measured from a 4-chamber view. The E/A ratio did not change, but the E deceleration time, velocity time integral of the E-A complex (E-A VTI), E/E-A VTI ratio, isovolumic relaxation time (IVRT), and diastolic time all significantly increased. The corresponding tissue Doppler parameter, Ea/Aa ratio, decreased by 25% (p = 0.035). The left atrial dimension and the ECHO index of left atrial pressure (E/Ea) significantly increased (p < 0.02). These data suggest that, with a long-axis and a 4-chamber view, the clinician can adequately determine diastolic function in the open-heart surgical patient. |
| | |
Authors:
|
A Schumacher; Ev Khojeini; Df Larson |
Related Documents
:
|
21926858 - Simultaneous measurement of left and right ventricular volumes and ejection fraction du... 12407848 - Evaluation of the left anterior descending coronary artery flow velocity by transthorac... 19594818 - New echocardiographic techniques in the evaluation of left ventricular mechanics in sub... 16631008 - Grading of myocardial dysfunction by tissue doppler echocardiography: a comparison betw... 508548 - The effect of intravenous disopyramide phosphate on recurrent paroxysmal tachycardias. 3285878 - Nifedipine in acute myocardial infarction: an assessment of left ventricular function, ... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Perfusion Volume: 23 ISSN: 0267-6591 ISO Abbreviation: Perfusion Publication Date: 2008 Sep |
Date Detail:
|
Created Date: 2009-04-06 Completed Date: 2009-07-16 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8700166 Medline TA: Perfusion Country: England |
Other Details:
|
Languages: eng Pagination: 291-6 Citation Subset: IM |
Affiliation:
|
Sarver Heart Center, College of Medicine, The University of Arizona, Tucson, AZ, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cardiotonic Agents / administration & dosage Diastole / drug effects Echocardiography, Transesophageal / methods* Female Heart / drug effects Isoproterenol / administration & dosage Mice Mice, Inbred C57BL Models, Animal Ventricular Dysfunction, Left / ultrasonography* |
| Grant Support | |
ID/Acronym/Agency:
|
R01 HL079206-01/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Cardiotonic Agents; 7683-59-2/Isoproterenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Barriers to the acceptance and use of autologous platelet gel.
Next Document: Effect of clenbuterol administration on the healthy murine heart.