Document Detail

ECG-gated 18F-FDG positron emission tomography.
MedLine Citation:
PMID:  12194677     Owner:  NLM     Status:  MEDLINE    
AIM: 18F-fluorodeoxyglucose (18F-FDG)-positron emission tomography (PET) provides information about myocardial glucose metabolism to diagnose myocardial viability. Additional information about the functional status is necessary. Comparison of tomographic metabolic PET with data from other imaging techniques is always hampered by some transfer uncertainty and scatter. We wanted to evaluate a new Fourier-based ECG-gated PET technique using a high resolution scanner providing both metabolic and functional data with respect to feasibility in patients with diseased left ventricles. METHODS: Forty-five patients with coronary artery disease and at least one left ventricular segment with severe hypokinesis or akinesis at biplane cineventriculography were included. A new Fourier-based ECG-gated metabolic 18F-FDG-PET was performed in these patients. Function at rest and 18F-FDG uptake were examined in the PET study using a 36-segment model. RESULTS: Segmental comparison with ventriculography revealed a high reliability in identifying dysfunctional segments (> 96%). 18F-FDG uptake of normokinetic/hypokinetic/akinetic segments was 75.4 +/- 7.5, 65.3 +/- 10.5, and 35.9 +/- 15.2% (p < 0.001). In segments > or = 70% 18F-FDG uptake no akinesia was observed. No residual function was found below 40% 18F-FDG uptake. An additional dobutamine test was performed and revealed inotropic reserve (viability) in 42 akinetic segments and 45 hypokinetic segments. CONCLUSION: ECG-gated metabolic PET with pixel-based Fourier smoothing provides reliable data on regional function. Assessment of metabolism and function makes complete judgement of segmental status feasible within a single study without any transfer artefacts or test-to-test variability. The results indicate the presence of considerable amounts of viable myocardium in regions with an uptake of 40-50% 18F-FDG.
Hans Martin Hoffmeister; Uwe Helber; Andreas Franow; Ulrich Feine; Roland Bares; Ludger Seipel; Wolfgang Müller-Schauenburg
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Publication Detail:
Type:  Comparative Study; Journal Article; Validation Studies    
Journal Detail:
Title:  The international journal of cardiovascular imaging     Volume:  18     ISSN:  1569-5794     ISO Abbreviation:  Int J Cardiovasc Imaging     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-08-26     Completed Date:  2003-02-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100969716     Medline TA:  Int J Cardiovasc Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  363-72     Citation Subset:  IM    
Klinik für Kardiologie und Allgemeine Innere Medizin, Städtisches Klinikum Solingen, Germany.
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MeSH Terms
Coronary Disease / radionuclide imaging*
Dobutamine / diagnostic use
Fluorodeoxyglucose F18 / diagnostic use*
Gated Blood-Pool Imaging
Middle Aged
Radiopharmaceuticals / diagnostic use*
Tomography, Emission-Computed*
Ventricular Function, Left / physiology*
Reg. No./Substance:
0/Radiopharmaceuticals; 34368-04-2/Dobutamine; 63503-12-8/Fluorodeoxyglucose F18

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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