Document Detail

The ECG changes due to altitude and to catecholamines.
MedLine Citation:
PMID:  6096139     Owner:  NLM     Status:  MEDLINE    
In order to distinguish the effects of beta-receptor stimulation on the ECG from other factors during short-term adjustment to hypoxic aerohypoxia, the ECG of 19 volunteers were compared during moderately acute, stepwise exposure to high altitude (6,000 m) in a low pressure chamber, once with and once without beta-receptor blockade (propranolol), and after isoprenaline inhalation at ground level. The results show that beta-receptor stimulation accounts mainly for most ECG changes during altitude exposure, i.e., for the shortening of R-R interval, the lengthening of Q-T and in particular for the ST-T flattening, the latter therefore being only an indirect sign of hypoxia. After exclusion of the catecholamines, the minor but still significant ECG changes at altitude (shortening of R-R interval, increase of P wave, prolongation of P-Q, deviation of the R vector, T wave flattening in the left precordial leads) may be attributed to other, so far undefined factors, such as cardiac hypoxia, vagal withdrawal, or increase of pulmonary resistance.
P Saurenmann; E A Koller
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of applied physiology and occupational physiology     Volume:  53     ISSN:  0301-5548     ISO Abbreviation:  Eur J Appl Physiol Occup Physiol     Publication Date:  1984  
Date Detail:
Created Date:  1985-02-06     Completed Date:  1985-02-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0410266     Medline TA:  Eur J Appl Physiol Occup Physiol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  35-42     Citation Subset:  IM; S    
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MeSH Terms
Altitude Sickness / physiopathology*
Anoxia / physiopathology*
Catecholamines / physiology*
Heart Rate / drug effects
Isoproterenol / pharmacology*
Myocardial Contraction / drug effects
Propranolol / pharmacology
Receptors, Adrenergic, beta / drug effects
Respiration / drug effects
Reg. No./Substance:
0/Catecholamines; 0/Receptors, Adrenergic, beta; 525-66-6/Propranolol; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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