Document Detail


ECG body surface mapping changes in type 1 diabetic patients with and without autonomic neuropathy.
MedLine Citation:
PMID:  19537926     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
ECG body surface mapping (BSM) parameters in patients with diabetes mellitus Type 1 (DM1) are significantly different comparing to healthy non-diabetic subjects. Hypothesis that these changes are more pronounced in DM1 patients with autonomic neuropathy (AN) was tested. The parameters of BSM were registered by diagnostic system Cardiag 112.2 in 54 DM1 patients including 25 with AN and 30 control subjects. AN was diagnosed according to Ewing criteria when two or more Ewing tests were abnormal. In classic 12-lead ECG the heart rate was increased, QRS and QT shortened (p<0.01) and QT(C) prolonged in DM1 patients. The VCG measurement of QRS-STT angles and spatial QRS-STT angle showed non-significant differences. The absolute values of maximum and minimum in depolarization and repolarization isopotential, isointegral, isoarea maps were significantly different in DM1 patients in comparison with controls (p<0.01). The changes were more pronounced in DM1 patients with AN than in DM patients without AN (p<0.05). The QT duration measured in 82 leads of thorax was significantly shortened in 68 leads of both groups of DM 1 patients (p<0.01) when compared with controls. In 34 of them this shortening was more pronounced in DM1 patients with AN than in DM1 patients without AN (p<0.05). The results showed that the method of ECG BSM is capable to confirm the presence of autonomic neuropathy in diabetic patients.
Authors:
S Palová; K Szabo; J Charvát; J Slavícek; E Medová; M Mlcek; O Kittnar
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Publication Detail:
Type:  Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-06-19
Journal Detail:
Title:  Physiological research / Academia Scientiarum Bohemoslovaca     Volume:  59     ISSN:  0862-8408     ISO Abbreviation:  Physiol Res     Publication Date:  2010  
Date Detail:
Created Date:  2010-05-20     Completed Date:  2010-08-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9112413     Medline TA:  Physiol Res     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  203-9     Citation Subset:  IM    
Affiliation:
Department of Medicine, Second Medical Faculty, Charles University, Prague, Czech Republic.
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MeSH Terms
Descriptor/Qualifier:
Adult
Autonomic Nervous System Diseases / diagnosis*,  physiopathology
Body Surface Potential Mapping / methods*
Diabetes Mellitus, Type 1 / physiopathology*
Diabetic Neuropathies / diagnosis*,  physiopathology
Electrocardiography / methods*
Female
Heart Rate / physiology
Humans
Male

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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