Document Detail

EBV gene expression, EBNA antibody responses and EBV+ peripheral blood lymphocytes in post-transplant lymphoproliferative disease.
MedLine Citation:
PMID:  7858507     Owner:  NLM     Status:  MEDLINE    
Epstein-Barr virus (EBV) is associated with the development of several B cell malignancies including Burkitt's lymphoma (BL), post-transplant lymphoproliferative disease (PTLD), and AIDS-related lymphomas. The latter two diseases result from EBV-driven B cell proliferation in the absence of normal immunosurveillance and as such, represent a heterogenous family of lymphoproliferative disorders. This article reviews studies on EBV gene expression and antibody development in PTLD and introduces recent information on the levels of EBV+ peripheral blood lymphocytes to discuss possible mechanisms of pathogenesis under varying conditions of immunosuppression.
J L McKnight; H Cen; S A Riddler; M C Breinig; P A Williams; M Ho; P S Joseph
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  15     ISSN:  1042-8194     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1995-03-20     Completed Date:  1995-03-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  9-16     Citation Subset:  IM    
Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261.
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MeSH Terms
Antibodies, Viral / biosynthesis*,  immunology
Antigens, Viral / immunology*
B-Lymphocytes / virology
DNA-Binding Proteins / immunology*
Epstein-Barr Virus Nuclear Antigens
Gene Expression Regulation, Viral*
Herpesviridae Infections / genetics*,  immunology,  transmission
Herpesvirus 4, Human / genetics*,  immunology,  physiology
Immunocompromised Host
Immunologic Surveillance
Immunosuppression / adverse effects*
Lymphoproliferative Disorders / etiology,  immunology,  virology*
Mice, SCID
Middle Aged
Postoperative Complications / etiology,  immunology,  virology*
Transplantation* / adverse effects
Tumor Virus Infections / genetics*,  immunology,  transmission
Viral Proteins / biosynthesis*,  genetics,  immunology
Virus Activation
Grant Support
2 SO7 RR05451-26/RR/NCRR NIH HHS; 2 SO7 RR05451-27/RR/NCRR NIH HHS; 2 SO7 RR05451-28/RR/NCRR NIH HHS
Reg. No./Substance:
0/Antibodies, Viral; 0/Antigens, Viral; 0/DNA-Binding Proteins; 0/Epstein-Barr Virus Nuclear Antigens; 0/Viral Proteins

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