Document Detail

EBV LMP-1 negatively regulates expression and pro-apoptotic activity of Par-4 in nasopharyngeal carcinoma cells.
MedLine Citation:
PMID:  19250735     Owner:  NLM     Status:  MEDLINE    
Latent membrane protein-1 (LMP-1) of the Epstein-Barr virus (EBV) is closely associated with nasopharyngeal carcinoma (NPC), and in this study we sought to determine whether the pro-apoptotic activity of prostate apoptosis response-4 (Par-4) is modulated by LMP-1 in NPC cells. We found that LMP-1 diminished the pro-apoptotic activity of Par-4 and negatively regulated Par-4 protein by de novo synthesis; moreover, although LMP-1 accelerated a Par-4 activator, PKA, we demonstrated that LMP-1 also activated the PI3K/Akt pathway and increased Bcl-2 expression to suppress the activity of Par-4. Consequently, our results revealed a novel negative action of LMP-1 on the pro-apoptosis protein Par-4 by the coordination of multiple signaling pathways.
Jeng-Woei Lee; Po-Fan Liu; Lee-Ping Hsu; Peir-Rong Chen; Chung-Hsing Chang; Wen-Ling Shih
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-02-27
Journal Detail:
Title:  Cancer letters     Volume:  279     ISSN:  1872-7980     ISO Abbreviation:  Cancer Lett.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-05-11     Completed Date:  2009-06-12     Revised Date:  2012-06-22    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  193-201     Citation Subset:  IM    
Department and Institute of Life Science, College of Life Science, Tzu-Chi University, No. 701, Zhongyang Rd., Sec. 3, Hualien 97004, Taiwan.
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MeSH Terms
Apoptosis / physiology*
Apoptosis Regulatory Proteins / biosynthesis,  physiology*
Cell Line, Tumor
Cyclic AMP-Dependent Protein Kinases / metabolism
Gene Expression Regulation, Neoplastic
Nasopharyngeal Neoplasms / metabolism*,  pathology
Phosphatidylinositol 3-Kinases / metabolism
Proto-Oncogene Proteins c-akt / metabolism
Proto-Oncogene Proteins c-bcl-2 / metabolism
Signal Transduction / physiology
Viral Matrix Proteins / physiology*
Reg. No./Substance:
0/Apoptosis Regulatory Proteins; 0/EBV-associated membrane antigen, Epstein-Barr virus; 0/Proto-Oncogene Proteins c-bcl-2; 0/Viral Matrix Proteins; 0/prostate apoptosis response-4 protein; EC 2.7.1.-/Phosphatidylinositol 3-Kinases; EC protein, human; EC Proteins c-akt; EC AMP-Dependent Protein Kinases

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