| EBV LMP-1 negatively regulates expression and pro-apoptotic activity of Par-4 in nasopharyngeal carcinoma cells. | |
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MedLine Citation:
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PMID: 19250735 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Latent membrane protein-1 (LMP-1) of the Epstein-Barr virus (EBV) is closely associated with nasopharyngeal carcinoma (NPC), and in this study we sought to determine whether the pro-apoptotic activity of prostate apoptosis response-4 (Par-4) is modulated by LMP-1 in NPC cells. We found that LMP-1 diminished the pro-apoptotic activity of Par-4 and negatively regulated Par-4 protein by de novo synthesis; moreover, although LMP-1 accelerated a Par-4 activator, PKA, we demonstrated that LMP-1 also activated the PI3K/Akt pathway and increased Bcl-2 expression to suppress the activity of Par-4. Consequently, our results revealed a novel negative action of LMP-1 on the pro-apoptosis protein Par-4 by the coordination of multiple signaling pathways. |
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Authors:
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Jeng-Woei Lee; Po-Fan Liu; Lee-Ping Hsu; Peir-Rong Chen; Chung-Hsing Chang; Wen-Ling Shih |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-02-27 |
Journal Detail:
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Title: Cancer letters Volume: 279 ISSN: 1872-7980 ISO Abbreviation: Cancer Lett. Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-05-11 Completed Date: 2009-06-12 Revised Date: 2012-06-22 |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 193-201 Citation Subset: IM |
Affiliation:
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Department and Institute of Life Science, College of Life Science, Tzu-Chi University, No. 701, Zhongyang Rd., Sec. 3, Hualien 97004, Taiwan. jwlee@mail.tcu.edu.tw |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis
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physiology* Apoptosis Regulatory Proteins / biosynthesis, physiology* Cell Line, Tumor Cyclic AMP-Dependent Protein Kinases / metabolism Gene Expression Regulation, Neoplastic Humans Nasopharyngeal Neoplasms / metabolism*, pathology Phosphatidylinositol 3-Kinases / metabolism Proto-Oncogene Proteins c-akt / metabolism Proto-Oncogene Proteins c-bcl-2 / metabolism Signal Transduction / physiology Viral Matrix Proteins / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Apoptosis Regulatory Proteins; 0/EBV-associated membrane antigen, Epstein-Barr virus; 0/Proto-Oncogene Proteins c-bcl-2; 0/Viral Matrix Proteins; 0/prostate apoptosis response-4 protein; EC 2.7.1.-/Phosphatidylinositol 3-Kinases; EC 2.7.11.1/AKT1 protein, human; EC 2.7.11.1/Proto-Oncogene Proteins c-akt; EC 2.7.11.11/Cyclic AMP-Dependent Protein Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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