| The E4 allele of apolipoprotein E is associated with increased restenosis after coronary angioplasty. | |
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MedLine Citation:
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PMID: 11885754 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study is to investigate the influence of the E4 allele of apolipoprotein E (apo E) on restenosis after percutaneous transluminal coronary angioplasty (PTCA). The subjects were 171 male patients with more than 75% luminal diameter stenotic lesions of the coronary artery who had undergone an elective initial PTCA. The PTCA was successful in 164 patients, 157 of whom completed a prospective 5 month coronary angiography (CAG) follow up to assess the degree of restenosis after their surgery. Patients with previous coronary artery bypass grafting surgery (CABG), 3 vessel disease, complete obstruction or calcified lesions of the coronary artery, cerebro-vascular disease (CVD), arteriosclerosis obliterans (ASO), and renal failure with hemodialysis were excluded, leaving 105 patients in the analysis. Subjects carrying the E4 allele (n = 22, Phenotype E4/2 = 2, E4/3 = 19, E4/4 = 1: E4 group) were well matched with non-carriers (n = 83, Phenotype E2/2 = 0, E3/2 = 4, E3/3 = 79: E3 group) for clinical, and pre-and post-PTCA angiographic features. The restenosis rates were significantly higher in the E4 group than in the E3 group (patient restenosis rate : 59.1 vs 33.7% p < 0.05, lesion restenosis rate: 51.8 vs 30.9% p < 0.05). These results suggest that the E4 allele is associated with a higher restenosis rate after PTCA. |
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Authors:
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H Tada |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Tokai journal of experimental and clinical medicine Volume: 26 ISSN: 0385-0005 ISO Abbreviation: Tokai J. Exp. Clin. Med. Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2002-03-11 Completed Date: 2002-09-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7704186 Medline TA: Tokai J Exp Clin Med Country: Japan |
Other Details:
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Languages: eng Pagination: 81-92 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Tokai University School of Medicine, Kanagawa, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Angioplasty, Transluminal, Percutaneous Coronary* Apolipoprotein E4 Apolipoproteins E / genetics, metabolism* Coronary Angiography Coronary Restenosis / epidemiology, metabolism*, radiography Coronary Stenosis / genetics, metabolism*, radiography, therapy* Heterozygote Humans Incidence Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Apolipoprotein E4; 0/Apolipoproteins E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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