Document Detail


The E3 ubiquitin ligase HOS1 regulates Arabidopsis flowering by mediating CONSTANS degradation under cold stress.
MedLine Citation:
PMID:  23135282     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The timing of flowering is coordinated by a web of gene regulatory networks that integrates developmental and environmental cues in plants. Light and temperature are two major environmental determinants that regulate flowering time. Although prolonged treatment with low nonfreezing temperatures accelerates flowering by stable repression of FLOWERING LOCUS C (FLC), repeated brief cold treatments delay flowering. Here, we report that intermittent cold treatments trigger the degradation of CONSTANS (CO), a central activator of photoperiodic flowering; daily treatments caused suppression of the floral integrator FLOWERING LOCUS T (FT) and delayed flowering. Cold-induced CO degradation is mediated via a ubiquitin/proteasome pathway that involves the E3 ubiquitin ligase HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE 1 (HOS1). HOS1-mediated CO degradation occurs independently of the well established cold response pathways. It is also independent of the light signaling repressor CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1) E3 ligase and light wavelengths. CO has been shown to play a key role in photoperiodic flowering. Here, we demonstrated that CO served as a molecular hub, integrating photoperiodic and cold stress signals into the flowering genetic pathways. We propose that the HOS1-CO module contributes to the fine-tuning of photoperiodic flowering under short term temperature fluctuations, which often occur during local weather disturbances.
Authors:
Jae-Hoon Jung; Pil Joon Seo; Chung-Mo Park
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-07
Journal Detail:
Title:  The Journal of biological chemistry     Volume:  287     ISSN:  1083-351X     ISO Abbreviation:  J. Biol. Chem.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-24     Completed Date:  2013-02-26     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  2985121R     Medline TA:  J Biol Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  43277-87     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological*
Arabidopsis / genetics,  metabolism*
Arabidopsis Proteins / genetics,  metabolism*
Cold-Shock Response / physiology*
DNA-Binding Proteins / genetics,  metabolism*
Flowering Tops / genetics,  metabolism*
Genetic Loci / physiology
Intracellular Signaling Peptides and Proteins / genetics,  metabolism*
Nuclear Proteins / genetics,  metabolism*
Photoperiod
Proteolysis
Transcription Factors / genetics,  metabolism*
Ubiquitin-Protein Ligases / genetics,  metabolism*
Chemical
Reg. No./Substance:
0/Arabidopsis Proteins; 0/CONSTANS protein, Arabidopsis; 0/DNA-Binding Proteins; 0/HOS1 protein, Arabidopsis; 0/Intracellular Signaling Peptides and Proteins; 0/Nuclear Proteins; 0/Transcription Factors; EC 6.3.2.19/COP1 protein, Arabidopsis; EC 6.3.2.19/Ubiquitin-Protein Ligases
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Mediator phosphorylation prevents stress response transcription during non-stress conditions.
Next Document:  PAX2 protein induces expression of cyclin D1 through activating AP-1 protein and promotes proliferat...