| E2F8 contributes to human hepatocellular carcinoma via regulating cell proliferation. | |
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MedLine Citation:
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PMID: 20068156 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The E2F family member of transcription factors includes the atypical member E2F8, which has been little studied in cancer. We report that E2F8 is strongly upregulated in human hepatocellular carcinoma (HCC), where it was evidenced to contribute to oncogenesis and progression. Ectopic overexpression of E2F8 promoted cell proliferation, colony formation, and tumorigenicity, whereas E2F8 knockdown inhibited these phenotypes, as documented in Huh-7, Focus, Hep3B, and YY-8103 HCC cell lines. Mechanistic analyses indicated that E2F8 could bind to regulatory elements of cyclin D1, regulating its transcription and promoting accumulation of S-phase cells. Together, our findings suggest that E2F8 contributes to the oncogenic potential of HCC and may constitute a potential therapeutic target in this disease. |
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Authors:
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Qing Deng; Qun Wang; Wei-Ying Zong; Da-Li Zheng; Yi-Xin Wen; Ke-Sheng Wang; Xiao-Mei Teng; Xin Zhang; Jian Huang; Ze-Guang Han |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-12 |
Journal Detail:
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Title: Cancer research Volume: 70 ISSN: 1538-7445 ISO Abbreviation: Cancer Res. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-15 Completed Date: 2010-03-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: United States |
Other Details:
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Languages: eng Pagination: 782-91 Citation Subset: IM |
Affiliation:
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National Human Genome Center, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201203, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carcinoma, Hepatocellular / genetics, metabolism, pathology* Cell Growth Processes / physiology Cell Line, Tumor Cyclin D1 / biosynthesis, genetics G1 Phase / physiology Humans Liver Neoplasms / genetics, metabolism, pathology* Male Mice Mice, Inbred BALB C Mice, Inbred NOD Mice, SCID RNA, Small Interfering / administration & dosage, genetics Repressor Proteins / biosynthesis*, genetics S Phase / physiology Transfection Up-Regulation |
| Chemical | |
Reg. No./Substance:
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0/E2F8 protein, human; 0/RNA, Small Interfering; 0/Repressor Proteins; 136601-57-5/Cyclin D1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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