Document Detail


E2F and cell cycle control: a double-edged sword.
MedLine Citation:
PMID:  12667479     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The E2F family of transcription factors plays a central role in regulating cellular proliferation by controlling the expression of both the genes required for cell cycle progression, particularly DNA synthesis, and the genes involved with apoptosis. E2F is regulated in a cell cycle-dependent manner, principally through its temporal association with pocket protein family members, the prototype member being the retinoblastoma tumor suppressor protein. Pocket proteins are, in turn, regulated through phosphorylation by cyclin-dependent kinase (cdk). The kinase activity of cyclin/cdk complexes is negatively regulated by cdk inhibitors, and thus both positive and negative growth regulatory signals impinge on E2F activity. Different E2F family members exhibit distinct cell cycle and apoptotic activities. Thus, E2F appears to play a pivotal role in coordinating events connected with proliferation, cell cycle arrest, and apoptosis.
Authors:
Craig Stevens; Nicholas B La Thangue
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Publication Detail:
Type:  Historical Article; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Archives of biochemistry and biophysics     Volume:  412     ISSN:  0003-9861     ISO Abbreviation:  Arch. Biochem. Biophys.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-04-01     Completed Date:  2003-05-13     Revised Date:  2014-07-22    
Medline Journal Info:
Nlm Unique ID:  0372430     Medline TA:  Arch Biochem Biophys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  157-69     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Cycle / genetics,  physiology*
Cell Cycle Proteins*
Cell Differentiation / physiology
Cell Division / physiology
DNA-Binding Proteins*
E2F Transcription Factors
Genes, Tumor Suppressor
History, 20th Century
Humans
Models, Biological
Oncogenes
Retinoblastoma Protein / metabolism
Transcription Factors / chemistry,  genetics,  history,  metabolism*
Grant Support
ID/Acronym/Agency:
13058//Cancer Research UK
Chemical
Reg. No./Substance:
0/Cell Cycle Proteins; 0/DNA-Binding Proteins; 0/E2F Transcription Factors; 0/Retinoblastoma Protein; 0/Transcription Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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