Document Detail


Escherichia coli nucleoside diphosphate kinase mutants depend on translesion DNA synthesis to prevent mutagenesis.
MedLine Citation:
PMID:  21725024     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Escherichia coli nucleoside diphosphate (NDP) kinase mutants have an increased frequency of spontaneous mutation, possibly due to uracil misincorporation into DNA. Here we show that NDP kinase mutants are dependent on translesion DNA synthesis, often a mutagenic form of DNA synthesis, to prevent mutagenesis.
Authors:
Jared Nordman; Andrew Wright
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-07-01
Journal Detail:
Title:  Journal of bacteriology     Volume:  193     ISSN:  1098-5530     ISO Abbreviation:  J. Bacteriol.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-12     Completed Date:  2011-10-06     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  2985120R     Medline TA:  J Bacteriol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4531-3     Citation Subset:  IM    
Affiliation:
Graduate Program in Molecular Microbiology, Sackler School of Graduate Biomedical Science, Tufts University School of Medicine, Boston, MA 02111, USA.
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MeSH Terms
Descriptor/Qualifier:
DNA Damage
DNA Replication*
DNA, Bacterial / genetics*,  metabolism
DNA-Directed DNA Polymerase / metabolism
Escherichia coli / enzymology,  genetics*
Escherichia coli Proteins / genetics,  metabolism*
Gene Expression Regulation, Bacterial
Mutagenesis*
Mutation
Nucleoside-Diphosphate Kinase / genetics,  metabolism*
Plasmids
Uracil / metabolism
beta-Galactosidase / metabolism
Chemical
Reg. No./Substance:
0/DNA, Bacterial; 0/Escherichia coli Proteins; 66-22-8/Uracil; EC 2.7.4.6/Nucleoside-Diphosphate Kinase; EC 2.7.7.7/DNA-Directed DNA Polymerase; EC 3.2.1.23/beta-Galactosidase
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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