Document Detail

E-057 Correlation between Angiographic Transit Times and Neurological Status in Patients with Aneurysmal Subarachnoid Haemorrhage.
MedLine Citation:
PMID:  25064976     Owner:  NLM     Status:  In-Data-Review    
INTRODUCTION: The use of digital subtraction angiography (DSA) for semi-quantitative cerebral blood flow (CBF) assessment is a new method. In this report we sought to correlate angiographic transit times (TT) in patients with aneurysmal subarachnoid haemorrhage (aSAH) in relation to Hunt &Hess (H&H) grade.
METHODS: A cohort of 28 patients with aSAH were included. Demographic variables, neurological status, and comorbidities were collected. We developed a method to measure CBF by colour-coding reconstruction from DSA contrast intensity. Regions of interest were chosen over major cerebral vessels (see legend Figure 1). The estimated TT included Time-To-Peak (TTP) from 0-100% intensity (TTP-100,), TTP from 25-100% (TTP25--00), and TT from 100--0% (TT100--). Student t-test was used to compare TT between group 1 (H&H 1-2) and 2 (H&H 3-5).
RESULTS: There was no difference in demographic factors between groups 1 (n = 10) and 2 (n = 18). The majority of patients in-group 2 (all except 3) had an external ventricular catheter with normal intracranial-pressure documented during DSA. There was a strong correlation in all TT between M1, M2, A1 and A2. There was a statistically significant difference in M1-TTP-100, between groups 1 and 2 (1.98 vs. 2.43 sec, p = 0.005), M1-TTP25--00 (1.78 vs. 2.7 sec, p = 0.003) and in M1-TT100-- (4.68 vs. 6.27 sec, p = 0.012) respectively. Similar difference were observed in A1; A1-TTP0-100 (1.84 vs. 2.18 sec, p = 0.001), A1-TTP25-100, (1.63 vs. 2.27 sec, p = 0.001) and in A1-TT100-10(4.24 vs. 5.12 sec, p = 0.0015, and for the M2 region; M2-TTP0-100, (2.03 vs. 2.64 sec, p = 0.001), M2-TTP25-100, (1.83 vs. 2.8 sec, p = 0.001) and in M2-TT100-10 (4.68 vs.6.2 sec, p = 0.012) (Figures 2 and 3).
CONCLUSION: The DSA TT showed significant correlation with H&H grade. TT delays appear to be independent of increased intracranial pressure and may be an indicators of decreased cerebral perfusion in patients with higher H&H grade. The method may serve as an indirect technique for cerebral blood flow assessment in the angiography suite. neurintsurg;6/Suppl_1/A64-b/F1F1F1 Abstract E-057 Figure 1 Transit times (T-100-10) in major cerebral arteries in a patient with H&H grade I(A) and grade V(B) aSAH neurintsurg;6/Suppl_1/A64-b/F2F2F2 Abstract E-057 Figure 2 M1 Transit tim100-10 (TT-100-10) values in modified H&H groups
DISCLOSURES: A. Ivanov: None. C. Hsu: None. A. Linninger: None. S. Amin-Hanjani: None. V. Aletich: 2; C; Covedien, Codman. F. Charbel: None. A. Alaraj: None.
A Ivanov; C Hsu; A Linninger; S Amin-Hanjani; V Aletich; F Charbel; A Alaraj
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurointerventional surgery     Volume:  6 Suppl 1     ISSN:  1759-8486     ISO Abbreviation:  J Neurointerv Surg     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-07-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101517079     Medline TA:  J Neurointerv Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  A64-5     Citation Subset:  IM    
Copyright Information:
© 2014, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to
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