Document Detail


Dystrophin: from non-ischemic cardiomyopathy to ischemic cardiomyopathy.
MedLine Citation:
PMID:  18562127     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dystrophin and its associated proteins form a scaffold underneath the cardiomyocyte membrane and connect the intracellular cytoskeleton to the extracellular matrix. Dystrophin localizes at the X chromosome, whose mutations might result in Duchenne muscular dystrophy, Becker muscular dystrophy and X-linked dilated cardiomyopathy. In addition to these genetic dilated cardiomyopathies, some acquired dilated cardiomyopathy like viral dilated cardiomyopathy is also related to dystrophin disruption or aberrant cleavage. In this review, we summarize the structure and distribution of dystrophin and researches of dystrophin in genetic and viral dilated cardiomyopathy. Moreover, we hypothesize that dystrophin play a critical role in ventricular remodeling in ischemic myocardium and treatment targeting restoration of dystrophin onto membrane could benefit for ischemic cardiomyopathy.
Authors:
Qiang Sun Zheng; Wan Gang Guo; Zi Fan Lu; Xiao Qin Shi; Fei Fei Su; Hua Li
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Publication Detail:
Type:  Journal Article; Review     Date:  2008-06-17
Journal Detail:
Title:  Medical hypotheses     Volume:  71     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-07-28     Completed Date:  2008-10-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  434-8     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China. tdxnsys@fmmu.edu.cn
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MeSH Terms
Descriptor/Qualifier:
Cardiomyopathies / genetics*
Dystrophin / genetics,  metabolism*
Glycoproteins / metabolism
Humans
Myocardial Ischemia / genetics*
Ventricular Remodeling / physiology*
Chemical
Reg. No./Substance:
0/Dystrophin; 0/Glycoproteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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